Association between Vitamin D levels and allergy-related outcomes vary by race and other factors

Ganesa Wegienka, Suzanne Havstad, Edward M. Zoratti, Haejin Kim, Dennis Randall Ownby, Christine Cole Johnson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background Allergy-related studies that include biological measurements of Vitamin D preceding well-measured outcomes are needed. Objective We sought to examine the associations between early-life Vitamin D levels and the development of allergy-related outcomes in the racially diverse Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort. Methods 25-HydroxyVitamin D (25[OH]D) levels were measured in stored blood samples from pregnancy, cord blood, and age 2 years. Logistic regression models were used to calculate odds ratios (ORs) with 95% CIs for a 5 ng/mL increase in 25(OH)D levels for the following outcomes at age 2 years: eczema, skin prick tests (SPTs), increased allergen-specific IgE level (≥0.35 IU/mL), and doctor's diagnosis of asthma (3-6 years). Results Prenatal 25(OH)D levels were inversely associated with eczema (OR, 0.85; 95% CI, 0.75-0.96). The association was stronger in white children (white children: OR, 0.79; 95% CI, 0.57-1.09; black children: OR, 0.96; 95% CI, 0.82-1.12), although this was not statistically significant. Cord blood 25(OH)D levels were inversely associated with having 1 or more positive SPT responses and aeroallergen sensitization. Both associations were statistically significant in white children (positive SPT response: OR, 0.50; 95% CI, 0.32-0.80; ≥1 aeroallergen sensitization: OR, 0.50; 95% CI, 0.28-0.92) in contrast with black children (positive SPT response: OR, 0.88; 95% CI, 0.68-1.14; ≥1 aeroallergen sensitization: OR, 0.85; 95% CI, 0.65-1.11). 25(OH)D levels measured concurrently with outcome assessment were inversely associated with aeroallergen sensitization (OR, 0.79; 95% CI, 0.66-0.96) only among black children (white children: OR, 1.21; 95% CI, 0.87-1.69). Conclusions Prenatal and cord blood 25(OH)D levels were associated with some allergy-related outcomes, with a general pattern indicating that children with higher 25(OH)D levels tend to have fewer allergy-related outcomes.

Original languageEnglish (US)
Pages (from-to)1309-1314.e4
JournalJournal of Allergy and Clinical Immunology
Volume136
Issue number5
DOIs
StatePublished - Nov 1 2015

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Vitamin D
Hypersensitivity
Odds Ratio
Skin Tests
Fetal Blood
Eczema
Asthma
Logistic Models
Allergens
Immunoglobulin E
Longitudinal Studies
Outcome Assessment (Health Care)
Parturition
Pregnancy
Health

Keywords

  • IgE
  • Vitamin D
  • allergy
  • asthma
  • eczema
  • racial differences

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Association between Vitamin D levels and allergy-related outcomes vary by race and other factors. / Wegienka, Ganesa; Havstad, Suzanne; Zoratti, Edward M.; Kim, Haejin; Ownby, Dennis Randall; Johnson, Christine Cole.

In: Journal of Allergy and Clinical Immunology, Vol. 136, No. 5, 01.11.2015, p. 1309-1314.e4.

Research output: Contribution to journalArticle

Wegienka, Ganesa ; Havstad, Suzanne ; Zoratti, Edward M. ; Kim, Haejin ; Ownby, Dennis Randall ; Johnson, Christine Cole. / Association between Vitamin D levels and allergy-related outcomes vary by race and other factors. In: Journal of Allergy and Clinical Immunology. 2015 ; Vol. 136, No. 5. pp. 1309-1314.e4.
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abstract = "Background Allergy-related studies that include biological measurements of Vitamin D preceding well-measured outcomes are needed. Objective We sought to examine the associations between early-life Vitamin D levels and the development of allergy-related outcomes in the racially diverse Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort. Methods 25-HydroxyVitamin D (25[OH]D) levels were measured in stored blood samples from pregnancy, cord blood, and age 2 years. Logistic regression models were used to calculate odds ratios (ORs) with 95{\%} CIs for a 5 ng/mL increase in 25(OH)D levels for the following outcomes at age 2 years: eczema, skin prick tests (SPTs), increased allergen-specific IgE level (≥0.35 IU/mL), and doctor's diagnosis of asthma (3-6 years). Results Prenatal 25(OH)D levels were inversely associated with eczema (OR, 0.85; 95{\%} CI, 0.75-0.96). The association was stronger in white children (white children: OR, 0.79; 95{\%} CI, 0.57-1.09; black children: OR, 0.96; 95{\%} CI, 0.82-1.12), although this was not statistically significant. Cord blood 25(OH)D levels were inversely associated with having 1 or more positive SPT responses and aeroallergen sensitization. Both associations were statistically significant in white children (positive SPT response: OR, 0.50; 95{\%} CI, 0.32-0.80; ≥1 aeroallergen sensitization: OR, 0.50; 95{\%} CI, 0.28-0.92) in contrast with black children (positive SPT response: OR, 0.88; 95{\%} CI, 0.68-1.14; ≥1 aeroallergen sensitization: OR, 0.85; 95{\%} CI, 0.65-1.11). 25(OH)D levels measured concurrently with outcome assessment were inversely associated with aeroallergen sensitization (OR, 0.79; 95{\%} CI, 0.66-0.96) only among black children (white children: OR, 1.21; 95{\%} CI, 0.87-1.69). Conclusions Prenatal and cord blood 25(OH)D levels were associated with some allergy-related outcomes, with a general pattern indicating that children with higher 25(OH)D levels tend to have fewer allergy-related outcomes.",
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AU - Wegienka, Ganesa

AU - Havstad, Suzanne

AU - Zoratti, Edward M.

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AU - Ownby, Dennis Randall

AU - Johnson, Christine Cole

PY - 2015/11/1

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N2 - Background Allergy-related studies that include biological measurements of Vitamin D preceding well-measured outcomes are needed. Objective We sought to examine the associations between early-life Vitamin D levels and the development of allergy-related outcomes in the racially diverse Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort. Methods 25-HydroxyVitamin D (25[OH]D) levels were measured in stored blood samples from pregnancy, cord blood, and age 2 years. Logistic regression models were used to calculate odds ratios (ORs) with 95% CIs for a 5 ng/mL increase in 25(OH)D levels for the following outcomes at age 2 years: eczema, skin prick tests (SPTs), increased allergen-specific IgE level (≥0.35 IU/mL), and doctor's diagnosis of asthma (3-6 years). Results Prenatal 25(OH)D levels were inversely associated with eczema (OR, 0.85; 95% CI, 0.75-0.96). The association was stronger in white children (white children: OR, 0.79; 95% CI, 0.57-1.09; black children: OR, 0.96; 95% CI, 0.82-1.12), although this was not statistically significant. Cord blood 25(OH)D levels were inversely associated with having 1 or more positive SPT responses and aeroallergen sensitization. Both associations were statistically significant in white children (positive SPT response: OR, 0.50; 95% CI, 0.32-0.80; ≥1 aeroallergen sensitization: OR, 0.50; 95% CI, 0.28-0.92) in contrast with black children (positive SPT response: OR, 0.88; 95% CI, 0.68-1.14; ≥1 aeroallergen sensitization: OR, 0.85; 95% CI, 0.65-1.11). 25(OH)D levels measured concurrently with outcome assessment were inversely associated with aeroallergen sensitization (OR, 0.79; 95% CI, 0.66-0.96) only among black children (white children: OR, 1.21; 95% CI, 0.87-1.69). Conclusions Prenatal and cord blood 25(OH)D levels were associated with some allergy-related outcomes, with a general pattern indicating that children with higher 25(OH)D levels tend to have fewer allergy-related outcomes.

AB - Background Allergy-related studies that include biological measurements of Vitamin D preceding well-measured outcomes are needed. Objective We sought to examine the associations between early-life Vitamin D levels and the development of allergy-related outcomes in the racially diverse Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort. Methods 25-HydroxyVitamin D (25[OH]D) levels were measured in stored blood samples from pregnancy, cord blood, and age 2 years. Logistic regression models were used to calculate odds ratios (ORs) with 95% CIs for a 5 ng/mL increase in 25(OH)D levels for the following outcomes at age 2 years: eczema, skin prick tests (SPTs), increased allergen-specific IgE level (≥0.35 IU/mL), and doctor's diagnosis of asthma (3-6 years). Results Prenatal 25(OH)D levels were inversely associated with eczema (OR, 0.85; 95% CI, 0.75-0.96). The association was stronger in white children (white children: OR, 0.79; 95% CI, 0.57-1.09; black children: OR, 0.96; 95% CI, 0.82-1.12), although this was not statistically significant. Cord blood 25(OH)D levels were inversely associated with having 1 or more positive SPT responses and aeroallergen sensitization. Both associations were statistically significant in white children (positive SPT response: OR, 0.50; 95% CI, 0.32-0.80; ≥1 aeroallergen sensitization: OR, 0.50; 95% CI, 0.28-0.92) in contrast with black children (positive SPT response: OR, 0.88; 95% CI, 0.68-1.14; ≥1 aeroallergen sensitization: OR, 0.85; 95% CI, 0.65-1.11). 25(OH)D levels measured concurrently with outcome assessment were inversely associated with aeroallergen sensitization (OR, 0.79; 95% CI, 0.66-0.96) only among black children (white children: OR, 1.21; 95% CI, 0.87-1.69). Conclusions Prenatal and cord blood 25(OH)D levels were associated with some allergy-related outcomes, with a general pattern indicating that children with higher 25(OH)D levels tend to have fewer allergy-related outcomes.

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