Association of baseline inflammatory biomarkers with cancer mortality in the REGARDS cohort

Tomi Akinyemiju, Justin X. Moore, Maria Pisu, Michael Goodman, Virginia J. Howard, Monika Safford, Susan C. Gilchrist, Mary Cushman, Leann Long, Suzanne E. Judd

Research output: Contribution to journalArticle

Abstract

This study examines the association between inflammatory biomarkers and risk of cancer mortality by race. Data were obtained from 1,856 participants in the prospective REGARDS cohort who were cancer-free at baseline, and analyzed in relation to cancer mortality prospectively. Biomarkers were log-transformed and categorized into tertiles due to non-normal distributions, and Cox proportional hazard regression models were utilized to compute hazard ratios with 95% confidence intervals using robust sandwich methods. Individuals in the highest tertile of IL-6 had over a 12-fold increased risk of cancer mortality (HR: 12.97, 95% CI: 3.46-48.63); those in the highest tertile of IL-8 had over a 2-fold increased risk of cancer mortality (HR: 2.21, 95% CI: 0.86- 5.71), while those in the highest tertile of IL-10 had over a 3-fold increased risk of cancer mortality (HR: 3.06, 95% CI: 1.35-6.89). In race-stratified analysis, each unit increase in IL-6 was associated with increased risk of cancer mortality among African- Americans (HR: 3.88, 95% CI: 1.17-12.88) and Whites (5.25, 95% CI: 1.24-22.31). If replicated in larger, racially diverse prospective cohorts, these results suggest that cancer patients may benefit from clinical or lifestyle approaches to regulate systemic inflammation as a cancer prevention strategy.

Original languageEnglish (US)
Pages (from-to)4857-4867
Number of pages11
JournalOncotarget
Volume10
Issue number47
StatePublished - Aug 1 2019
Externally publishedYes

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Keywords

  • Cancer mortality
  • Inflammatory biomarkers
  • Obesity
  • Racial disparities

ASJC Scopus subject areas

  • Oncology

Cite this

Akinyemiju, T., Moore, J. X., Pisu, M., Goodman, M., Howard, V. J., Safford, M., Gilchrist, S. C., Cushman, M., Long, L., & Judd, S. E. (2019). Association of baseline inflammatory biomarkers with cancer mortality in the REGARDS cohort. Oncotarget, 10(47), 4857-4867.