Association of lymphoid malignancies and Philadelphia-chromosome negative myeloproliferative neoplasms: Clinical characteristics, therapy and outcome

Lucia Masarova, Kate J. Newberry, Sherry A. Pierce, Zeev Estrov, Jorge E. Cortes, Hagop M. Kantarjian, Srdan Verstovsek

Research output: Contribution to journalArticle

Abstract

The co-occurrence of myeloproliferative and lymphoproliferative neoplasms (MPN/LPN) has been reported, mostly in case reports. The aim of this study was to assess the characteristics and clinical course of the coexistent diseases. Among 9866 patients who presented to our institution from 1960 to 2014, 34 (0.3%) were diagnosed with MPN/LPN. LPN was diagnosed first in 16 patients, second in 15, and at the same time in 3. The time to secondary malignancy was longer when LPN was diagnosed first (119 vs 98 months). Myelofibrosis (41%), polycythemia vera (24%), and essential thrombocythemia (18%) were the most common MPNs, and non-Hodgkin lymphoma (50%) and chronic lymphocytic leukemia (32%) were the most common LPNs. Seventy-three percent of patients treated for MPN and 72% of those treated for LPN achieved a complete response. After a median follow-up from MPN diagnosis of 84 months, 16 patients are alive and 18 died (4 related to MPN and 2 LPN). Coexistent MPN/LPN is a rare event that does not appear to predict worse outcomes. Treatment choice is generally oriented towards controlling the prevalent disease; the other malignancy may influence treatment strategies in selected cases.

Original languageEnglish (US)
Pages (from-to)822-827
Number of pages6
JournalLeukemia Research
Volume39
Issue number8
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

Fingerprint

Philadelphia Chromosome
Neoplasms
Essential Thrombocythemia
Therapeutics
Polycythemia Vera
Primary Myelofibrosis
B-Cell Chronic Lymphocytic Leukemia
Non-Hodgkin's Lymphoma

Keywords

  • Clinical course
  • Concurrent
  • Lymphoproliferative neoplasm
  • Myeloproliferative neoplasm

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Association of lymphoid malignancies and Philadelphia-chromosome negative myeloproliferative neoplasms : Clinical characteristics, therapy and outcome. / Masarova, Lucia; Newberry, Kate J.; Pierce, Sherry A.; Estrov, Zeev; Cortes, Jorge E.; Kantarjian, Hagop M.; Verstovsek, Srdan.

In: Leukemia Research, Vol. 39, No. 8, 01.08.2015, p. 822-827.

Research output: Contribution to journalArticle

Masarova, Lucia ; Newberry, Kate J. ; Pierce, Sherry A. ; Estrov, Zeev ; Cortes, Jorge E. ; Kantarjian, Hagop M. ; Verstovsek, Srdan. / Association of lymphoid malignancies and Philadelphia-chromosome negative myeloproliferative neoplasms : Clinical characteristics, therapy and outcome. In: Leukemia Research. 2015 ; Vol. 39, No. 8. pp. 822-827.
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