Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma

William Greer Albergotti, Kara S. Davis, Shira Abberbock, Julie E. Bauman, James Ohr, David A. Clump, Dwight E. Heron, Umamaheswar Duvvuri, Seungwon Kim, Jonas T. Johnson, Robert L. Ferris

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background Pretreatment body mass index (BMI) >25 kg/m2 is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). Methods This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014. Patients were stratified by BMI status (>/<25 kg/m2). Univariate and multivariate analyses of survival were performed. Results 300 patients met our inclusion/exclusion criteria. Patients with a BMI >25 kg/m2 had a longer overall survival (HR = 0.49, P = 0.01) as well as a longer disease-specific survival (HR = 0.43, P = 0.02). Overall survival remained significantly associated with high BMI on multivariate analysis (HR = 0.54, P = 0.04). Conclusions Pre-treatment normal or underweight BMI status is associated with worse overall survival in HPV+ OPSCC.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalOral Oncology
Volume60
DOIs
StatePublished - Sep 1 2016

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Papillomaviridae
Squamous Cell Carcinoma
Body Mass Index
Survival
Thinness
Head and Neck Neoplasms
Multivariate Analysis

Keywords

  • Body mass index
  • Human papillomavirus
  • Oropharyngeal squamous cell carcinoma
  • Survival

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma. / Albergotti, William Greer; Davis, Kara S.; Abberbock, Shira; Bauman, Julie E.; Ohr, James; Clump, David A.; Heron, Dwight E.; Duvvuri, Umamaheswar; Kim, Seungwon; Johnson, Jonas T.; Ferris, Robert L.

In: Oral Oncology, Vol. 60, 01.09.2016, p. 55-60.

Research output: Contribution to journalArticle

Albergotti, WG, Davis, KS, Abberbock, S, Bauman, JE, Ohr, J, Clump, DA, Heron, DE, Duvvuri, U, Kim, S, Johnson, JT & Ferris, RL 2016, 'Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma', Oral Oncology, vol. 60, pp. 55-60. https://doi.org/10.1016/j.oraloncology.2016.07.003
Albergotti, William Greer ; Davis, Kara S. ; Abberbock, Shira ; Bauman, Julie E. ; Ohr, James ; Clump, David A. ; Heron, Dwight E. ; Duvvuri, Umamaheswar ; Kim, Seungwon ; Johnson, Jonas T. ; Ferris, Robert L. / Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma. In: Oral Oncology. 2016 ; Vol. 60. pp. 55-60.
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AU - Ohr, James

AU - Clump, David A.

AU - Heron, Dwight E.

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AU - Ferris, Robert L.

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