TY - JOUR
T1 - Association of pro-inflammatory high-density lipoprotein cholesterol with clinical and laboratory variables in sickle cell disease
AU - Ataga, Kenneth I.
AU - Hinderliter, Alan
AU - Brittain, Julia Elizabeth
AU - Jones, Susan
AU - Xu, Hao
AU - Cai, Jianwen
AU - Kim, Soyoung
AU - Pritchard, Kirkwood A.
AU - Hillery, Cheryl A.
N1 - Publisher Copyright:
© W. S. Maney & Son Ltd 2015
PY - 2015
Y1 - 2015
N2 - Background: Although cholesterol levels are known to be decreased in sickle cell disease (SCD), the level of pro-inflammatory high-density lipoprotein cholesterol (proHDL) and its association with clinical complications and laboratory variables has not been evaluated. Design and methods: Plasma levels of total cholesterol, high-density lipoprotein cholesterol (HDL), proHDL, and selected clinical and laboratory variables were ascertained in a cohort of SCD patients and healthy African American control subjects in this single-center, cross-sectional study. Results: Although total cholesterol was significantly lower in SCD patients compared with control subjects, HDL and proHDL levels were similar in both the SCD and control groups. In univariate analyses, proHDL was correlated with echocardiography-derived tricuspid regurgitant jet velocity. ProHDL was higher in SCD patients with suspected pulmonary hypertension (PHT) compared to patients without suspected PHT. ProHDL was positively correlated with lactate dehydrogenase, total bilirubin, direct bilirubin, indirect bilirubin, prothrombin fragment 1+2, D-dimer, and thrombin–antithrombin complexes. In multivariable analyses, only higher lactate dehydrogenase and direct bilirubin levels were associated with higher levels of proHDL. Conclusions: SCD is characterized by hypocholesterolemia. Although proHDL is not increased in SCD patients compared with healthy controls, it is significantly associated with markers of liver disease. In addition, proHDL is associated with tricuspid regurgitant jet velocity and markers of coagulation, although these associations are not significant in multivariable analyses.
AB - Background: Although cholesterol levels are known to be decreased in sickle cell disease (SCD), the level of pro-inflammatory high-density lipoprotein cholesterol (proHDL) and its association with clinical complications and laboratory variables has not been evaluated. Design and methods: Plasma levels of total cholesterol, high-density lipoprotein cholesterol (HDL), proHDL, and selected clinical and laboratory variables were ascertained in a cohort of SCD patients and healthy African American control subjects in this single-center, cross-sectional study. Results: Although total cholesterol was significantly lower in SCD patients compared with control subjects, HDL and proHDL levels were similar in both the SCD and control groups. In univariate analyses, proHDL was correlated with echocardiography-derived tricuspid regurgitant jet velocity. ProHDL was higher in SCD patients with suspected pulmonary hypertension (PHT) compared to patients without suspected PHT. ProHDL was positively correlated with lactate dehydrogenase, total bilirubin, direct bilirubin, indirect bilirubin, prothrombin fragment 1+2, D-dimer, and thrombin–antithrombin complexes. In multivariable analyses, only higher lactate dehydrogenase and direct bilirubin levels were associated with higher levels of proHDL. Conclusions: SCD is characterized by hypocholesterolemia. Although proHDL is not increased in SCD patients compared with healthy controls, it is significantly associated with markers of liver disease. In addition, proHDL is associated with tricuspid regurgitant jet velocity and markers of coagulation, although these associations are not significant in multivariable analyses.
KW - Cholesterol
KW - Coagulation activation
KW - Pro-inflammatory HDL
KW - Pulmonary vasculopathy
KW - Sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=84929146687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929146687&partnerID=8YFLogxK
U2 - 10.1179/1607845414Y.0000000171
DO - 10.1179/1607845414Y.0000000171
M3 - Article
C2 - 24801127
AN - SCOPUS:84929146687
SN - 1024-5332
VL - 20
SP - 289
EP - 296
JO - Hematology
JF - Hematology
IS - 5
ER -