Association of serum VEGF levels with prefrontal cortex volume in schizophrenia

Anilkumar R Pillai, K. R. Howell, A. O. Ahmed, D. Weinberg, K. M. Allen, J. Bruggemann, R. Lenroot, D. Liu, C. Galletly, C. S. Weickert, T. W. Weickert

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A large body of evidence indicates alterations in brain regional cellular energy metabolism and blood flow in schizophrenia. Among the different molecules regulating blood flow, vascular endothelial growth factor (VEGF) is generally accepted as the major factor involved in the process of angiogenesis. In the present study, we examined whether peripheral VEGF levels correlate with changes in the prefrontal cortex (PFC) volume in patients with schizophrenia and in healthy controls. Whole-blood samples were obtained from 96 people with schizophrenia or schizoaffective disorder and 83 healthy controls. Serum VEGF protein levels were analyzed by enzyme-linked immunosorbent assay, whereas quantitative PCR was performed to measure interleukin-6 (IL-6, a pro-inflammatory marker implicated in schizophrenia) mRNA levels in the blood samples. Structural magnetic resonance imaging scans were obtained using a 3T Achieva scanner on a subset of 59 people with schizophrenia or schizoaffective disorder and 65 healthy controls, and prefrontal volumes were obtained using FreeSurfer software. As compared with healthy controls, individuals with schizophrenia had a significant increase in log-transformed mean serum VEGF levels (t(177)=2.9, P=0.005). A significant inverse correlation (r=-0.40, P=0.002) between serum VEGF and total frontal pole volume was found in patients with schizophrenia/schizoaffective disorder. Moreover, we observed a significant positive association (r=0.24, P=0.03) between serum VEGF and IL-6 mRNA levels in patients with schizophrenia. These findings suggest an association between serum VEGF and inflammation, and that serum VEGF levels are related to structural abnormalities in the PFC of people with schizophrenia.

Original languageEnglish (US)
Pages (from-to)686-692
Number of pages7
JournalMolecular Psychiatry
Volume21
Issue number5
DOIs
StatePublished - May 1 2016

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Prefrontal Cortex
Vascular Endothelial Growth Factor A
Schizophrenia
Serum
Psychotic Disorders
Interleukin-6
Messenger RNA
Energy Metabolism
Software
Enzyme-Linked Immunosorbent Assay
Magnetic Resonance Imaging
Inflammation
Polymerase Chain Reaction
Brain

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Pillai, A. R., Howell, K. R., Ahmed, A. O., Weinberg, D., Allen, K. M., Bruggemann, J., ... Weickert, T. W. (2016). Association of serum VEGF levels with prefrontal cortex volume in schizophrenia. Molecular Psychiatry, 21(5), 686-692. https://doi.org/10.1038/mp.2015.96

Association of serum VEGF levels with prefrontal cortex volume in schizophrenia. / Pillai, Anilkumar R; Howell, K. R.; Ahmed, A. O.; Weinberg, D.; Allen, K. M.; Bruggemann, J.; Lenroot, R.; Liu, D.; Galletly, C.; Weickert, C. S.; Weickert, T. W.

In: Molecular Psychiatry, Vol. 21, No. 5, 01.05.2016, p. 686-692.

Research output: Contribution to journalArticle

Pillai, AR, Howell, KR, Ahmed, AO, Weinberg, D, Allen, KM, Bruggemann, J, Lenroot, R, Liu, D, Galletly, C, Weickert, CS & Weickert, TW 2016, 'Association of serum VEGF levels with prefrontal cortex volume in schizophrenia', Molecular Psychiatry, vol. 21, no. 5, pp. 686-692. https://doi.org/10.1038/mp.2015.96
Pillai AR, Howell KR, Ahmed AO, Weinberg D, Allen KM, Bruggemann J et al. Association of serum VEGF levels with prefrontal cortex volume in schizophrenia. Molecular Psychiatry. 2016 May 1;21(5):686-692. https://doi.org/10.1038/mp.2015.96
Pillai, Anilkumar R ; Howell, K. R. ; Ahmed, A. O. ; Weinberg, D. ; Allen, K. M. ; Bruggemann, J. ; Lenroot, R. ; Liu, D. ; Galletly, C. ; Weickert, C. S. ; Weickert, T. W. / Association of serum VEGF levels with prefrontal cortex volume in schizophrenia. In: Molecular Psychiatry. 2016 ; Vol. 21, No. 5. pp. 686-692.
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