Association of the PTPN22/LYP gene with type 1 diabetes

Andrea K. Steck, Si Yang Liu, Kim McFann, Katherine J. Barriga, Sunanda R. Babu, George S. Eisenbarth, Marian J. Rewers, Jin Xiong She

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objectives: The goal of this study was to verify the association between type 1 diabetes (T1D) and the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene in non-Hispanic whites (NHWs) and Hispanics from Colorado. Subjects and methods: The C1858T single-nucleotide polymorphism within the PTPN22 gene was genotyped in 753 patients with T1D ascertained from the diabetes clinic at the Barbara Davis Center in Denver and 662 control population. Results: Both the PTPN22 CT genotype [odds ratio (OR) = 1.96; p < 0.0001] and TT genotype (OR = 4.41; p = 0.02) were significantly associated with T1D in the NHW population. While the association was stronger in subjects with non-HLA-DR3/4 genotypes than in those with the HLA-DR3/4 genotype, regression analyses did not reveal significant interaction between PTPN22 genotypes and HLA-DR3/4. The strength of the association was similar in males and females, patients diagnosed before and after age 10 yr, and in Hispanics and NHWs. Conclusion: In this study, we confirm that PTPN22 is associated with T1D in the Colorado population.

Original languageEnglish (US)
Pages (from-to)274-278
Number of pages5
JournalPediatric Diabetes
Volume7
Issue number5
DOIs
StatePublished - Oct 1 2006

Fingerprint

Non-Receptor Type 22 Protein Tyrosine Phosphatase
Type 1 Diabetes Mellitus
Genotype
HLA-DR3 Antigen
Genes
Hispanic Americans
Odds Ratio
Population
Single Nucleotide Polymorphism
Regression Analysis

Keywords

  • Case
  • Control study
  • HLA
  • LYP
  • PTPN22 gene
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Steck, A. K., Liu, S. Y., McFann, K., Barriga, K. J., Babu, S. R., Eisenbarth, G. S., ... She, J. X. (2006). Association of the PTPN22/LYP gene with type 1 diabetes. Pediatric Diabetes, 7(5), 274-278. https://doi.org/10.1111/j.1399-5448.2006.00202.x

Association of the PTPN22/LYP gene with type 1 diabetes. / Steck, Andrea K.; Liu, Si Yang; McFann, Kim; Barriga, Katherine J.; Babu, Sunanda R.; Eisenbarth, George S.; Rewers, Marian J.; She, Jin Xiong.

In: Pediatric Diabetes, Vol. 7, No. 5, 01.10.2006, p. 274-278.

Research output: Contribution to journalArticle

Steck, AK, Liu, SY, McFann, K, Barriga, KJ, Babu, SR, Eisenbarth, GS, Rewers, MJ & She, JX 2006, 'Association of the PTPN22/LYP gene with type 1 diabetes', Pediatric Diabetes, vol. 7, no. 5, pp. 274-278. https://doi.org/10.1111/j.1399-5448.2006.00202.x
Steck AK, Liu SY, McFann K, Barriga KJ, Babu SR, Eisenbarth GS et al. Association of the PTPN22/LYP gene with type 1 diabetes. Pediatric Diabetes. 2006 Oct 1;7(5):274-278. https://doi.org/10.1111/j.1399-5448.2006.00202.x
Steck, Andrea K. ; Liu, Si Yang ; McFann, Kim ; Barriga, Katherine J. ; Babu, Sunanda R. ; Eisenbarth, George S. ; Rewers, Marian J. ; She, Jin Xiong. / Association of the PTPN22/LYP gene with type 1 diabetes. In: Pediatric Diabetes. 2006 ; Vol. 7, No. 5. pp. 274-278.
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