Association study of androgen signaling pathway genes in polycystic ovary syndrome

Aline Ketefian, Michelle R. Jones, Ronald M. Krauss, Yii Der I. Chen, Richard S. Legro, Ricardo Azziz, Mark O. Goodarzi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective To evaluate genes involved in androgen receptor (AR) signaling as candidate genes for polycystic ovary syndrome (PCOS). Design Two groups of women with PCOS and control women (discovery and replication cohorts), were genotyped for single-nucleotide polymorphisms (SNPs) in eight genes for AR chaperones and co-chaperones: HSPA1A, HSPA8, ST13, STIP1, PTGES3, FKBP4, BAG1, and STUB1. Single-nucleotide polymorphisms were tested for association with PCOS status and with androgenic and metabolic parameters. Setting Tertiary referral center. Patient(s) Discovery cohort: 354 women with PCOS and 161 control women. Replication cohort: 397 women with PCOS and 306 control women. Intervention(s) Phenotypic and genotypic assessment. Main Outcome Measure(s) Single-nucleotide polymorphism genotypes, association with PCOS status, and androgenic and metabolic parameters. Result(s) In the discovery cohort, FKBP4 SNPs rs2968909 and rs4409904 were associated with lower odds of PCOS. This finding was not confirmed in the replication cohort analysis; however, when combining the two cohorts, rs4409904 was associated with lower odds of PCOS. In subjects with PCOS in the replication cohort as well as in the combined cohort, rs2968909 was associated with lower body mass index. Conclusion(s) Single-nucleotide polymorphisms in FKBP4, which codes for the AR co-chaperone FKBP52, may be associated with PCOS and body mass index in patients with PCOS. The remaining genes studied do not seem to be major contributors to the development of PCOS. These findings warrant confirmation in future studies, and genes encoding other androgen pathway components remain to be studied.

Original languageEnglish (US)
Pages (from-to)467-473.e4
JournalFertility and sterility
Volume105
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Polycystic Ovary Syndrome
Androgens
Genes
Single Nucleotide Polymorphism
Androgen Receptors
Body Mass Index
Tertiary Care Centers
Cohort Studies
Genotype
Outcome Assessment (Health Care)

Keywords

  • PCOS
  • androgen receptor
  • chaperones
  • co-chaperones

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Ketefian, A., Jones, M. R., Krauss, R. M., Chen, Y. D. I., Legro, R. S., Azziz, R., & Goodarzi, M. O. (2016). Association study of androgen signaling pathway genes in polycystic ovary syndrome. Fertility and sterility, 105(2), 467-473.e4. https://doi.org/10.1016/j.fertnstert.2015.09.043

Association study of androgen signaling pathway genes in polycystic ovary syndrome. / Ketefian, Aline; Jones, Michelle R.; Krauss, Ronald M.; Chen, Yii Der I.; Legro, Richard S.; Azziz, Ricardo; Goodarzi, Mark O.

In: Fertility and sterility, Vol. 105, No. 2, 01.02.2016, p. 467-473.e4.

Research output: Contribution to journalArticle

Ketefian, A, Jones, MR, Krauss, RM, Chen, YDI, Legro, RS, Azziz, R & Goodarzi, MO 2016, 'Association study of androgen signaling pathway genes in polycystic ovary syndrome', Fertility and sterility, vol. 105, no. 2, pp. 467-473.e4. https://doi.org/10.1016/j.fertnstert.2015.09.043
Ketefian A, Jones MR, Krauss RM, Chen YDI, Legro RS, Azziz R et al. Association study of androgen signaling pathway genes in polycystic ovary syndrome. Fertility and sterility. 2016 Feb 1;105(2):467-473.e4. https://doi.org/10.1016/j.fertnstert.2015.09.043
Ketefian, Aline ; Jones, Michelle R. ; Krauss, Ronald M. ; Chen, Yii Der I. ; Legro, Richard S. ; Azziz, Ricardo ; Goodarzi, Mark O. / Association study of androgen signaling pathway genes in polycystic ovary syndrome. In: Fertility and sterility. 2016 ; Vol. 105, No. 2. pp. 467-473.e4.
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abstract = "Objective To evaluate genes involved in androgen receptor (AR) signaling as candidate genes for polycystic ovary syndrome (PCOS). Design Two groups of women with PCOS and control women (discovery and replication cohorts), were genotyped for single-nucleotide polymorphisms (SNPs) in eight genes for AR chaperones and co-chaperones: HSPA1A, HSPA8, ST13, STIP1, PTGES3, FKBP4, BAG1, and STUB1. Single-nucleotide polymorphisms were tested for association with PCOS status and with androgenic and metabolic parameters. Setting Tertiary referral center. Patient(s) Discovery cohort: 354 women with PCOS and 161 control women. Replication cohort: 397 women with PCOS and 306 control women. Intervention(s) Phenotypic and genotypic assessment. Main Outcome Measure(s) Single-nucleotide polymorphism genotypes, association with PCOS status, and androgenic and metabolic parameters. Result(s) In the discovery cohort, FKBP4 SNPs rs2968909 and rs4409904 were associated with lower odds of PCOS. This finding was not confirmed in the replication cohort analysis; however, when combining the two cohorts, rs4409904 was associated with lower odds of PCOS. In subjects with PCOS in the replication cohort as well as in the combined cohort, rs2968909 was associated with lower body mass index. Conclusion(s) Single-nucleotide polymorphisms in FKBP4, which codes for the AR co-chaperone FKBP52, may be associated with PCOS and body mass index in patients with PCOS. The remaining genes studied do not seem to be major contributors to the development of PCOS. These findings warrant confirmation in future studies, and genes encoding other androgen pathway components remain to be studied.",
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