Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage

Angela K. Chua, Ricardo Azziz, Mark O. Goodarzi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Cytochrome P450-C17 enzyme (CYP17) is an important component of the androgen synthesis pathway, a pathway that is dysfunctional in polycystic ovary syndrome (PCOS). Variation in 11-beta hydroxysteroid dehydrogenase (HSD11B1) is associated with cortisone reductase deficiency, a condition with a phenotype similar to PCOS. Both CYP17 and HSD11B1 genes have been previously studied for their possible relationship with PCOS, yielding inconsistent results. In this study, we evaluated the association between variation in these genes and PCOS. Two-hundred and eighty-seven Caucasian PCOS women and 187 Caucasian controls were genotyped for single nucleotide polymorphisms (SNPs) that were specifically chosen to allow full coverage of CYP17 and HSD11B1, including four SNPs in CYP17 and eight SNPs in HSD11B1. SNP and haplotype association analyses were conducted. Our results indicate that variants in the two genes are not associated with PCOS, or with the quantitative traits characteristic of PCOS, suggesting that these genes are not major risk factors for the syndrome.

Original languageEnglish (US)
Article numbergas002
Pages (from-to)320-324
Number of pages5
JournalMolecular Human Reproduction
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2012

Fingerprint

Steroid 17-alpha-Hydroxylase
Polycystic Ovary Syndrome
Single Nucleotide Polymorphism
Genes
Cytochrome P-450 Enzyme System
11-beta-Hydroxysteroid Dehydrogenases
Haplotypes
Androgens
Phenotype

Keywords

  • CYP17
  • HSD11B1
  • Haplotype
  • Polycystic ovary syndrome
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Molecular Biology
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Cell Biology

Cite this

Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage. / Chua, Angela K.; Azziz, Ricardo; Goodarzi, Mark O.

In: Molecular Human Reproduction, Vol. 18, No. 6, gas002, 01.06.2012, p. 320-324.

Research output: Contribution to journalArticle

Chua, Angela K. ; Azziz, Ricardo ; Goodarzi, Mark O. / Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage. In: Molecular Human Reproduction. 2012 ; Vol. 18, No. 6. pp. 320-324.
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