Association study of four key folliculogenesis genes in polycystic ovary syndrome

K. Sproul, M. R. Jones, R. Mathur, R. Azziz, M. O. Goodarzi

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Polycystic ovaries and impaired fertility are the result of abnormal folliculogenesis. Our objective was to determine the role of four candidate folliculogenesis genes in the development of polycystic ovary syndrome (PCOS). Women with and without PCOS (335 cases; 198 controls) were genotyped for single nucleotide polymorphisms in GDF9, BMP15, AMH, and AMHR2. Variants in these genes were not associated with PCOS. Certain GDF9 variants were associated with hirsutism scores and parity in PCOS patients. GDF9 may thus serve as a modifier gene. These results suggest that inherited defects in folliculogenesis are not major factors in the genetic susceptibility to PCOS.

Original languageEnglish (US)
Pages (from-to)756-760
Number of pages5
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume117
Issue number6
DOIs
StatePublished - May 2010

Keywords

  • Folliculogenesis
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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