Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents /631/208/176/1988 /631/208/211 /14/1 article

Yutong Dong, Ying Huang, Bernard Gutin, Anas Raed, Yanbin Dong, Haidong Zhu

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9 Citations (Scopus)

Abstract

Emerging evidence suggests that epigenetics regulates telomere dynamics in adults. However, the relationship between these pathways in children and youth remains unknown. Thus, we examined this association in 542 healthy adolescents aged 14 to 18 years old (44.8% African Americans; 55.2% females). Global DNA methylation level (%5-mC) was quantified using ELISA method. Leukocyte telomere length (LTL) was defined as relative telomere to single copy gene (T/S) ratio. Multiple linear regression models, adjusted for age, gender, ethnicity, Tanner stage, BMI, PA, and batch effect, revealed that %5 mC was associated with LTL (adjusted β = 0.17, p < 0.01). %5 mC accounted for 5.0% of the variation for LTL. A significant gender interaction was identified (p < 0.01). There was an association between %5 mC and LTL in females (all ps < 0.01), but not in males. Further sensitivity analyses by race revealed similar associations in African Americans and whites (all ps < 0.03). The present study, for the first time, shows that lower levels of global DNA methylation are associated with shorter telomere lengths in youth, which may decrease genome stability and augment the susceptibility to diseases. Longitudinal studies are warranted to establish the effects of global DNA methylation on LTL maintenance over time.

Original languageEnglish (US)
Article number4210
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Telomere
DNA Methylation
Leukocytes
African Americans
Linear Models
Telomere Homeostasis
Genomic Instability
Disease Susceptibility
Epigenomics
Longitudinal Studies
Enzyme-Linked Immunosorbent Assay
Genes

ASJC Scopus subject areas

  • General

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Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents /631/208/176/1988 /631/208/211 /14/1 article. / Dong, Yutong; Huang, Ying; Gutin, Bernard; Raed, Anas; Dong, Yanbin; Zhu, Haidong.

In: Scientific Reports, Vol. 7, No. 1, 4210, 01.12.2017.

Research output: Contribution to journalArticle

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