Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease

Nagy Adel Youssef, Manal F. Abdelmalek, Martin Binks, Cynthia D. Guy, Alessia Omenetti, Alastair D. Smith, Anna Mae E. Diehl, Ayako Suzuki

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Depression and anxiety are common in patients with nonalcoholic fatty liver disease (NAFLD). However, their associations with histological severity of NAFLD are unknown. Aim: This study examined the association(s) of depression, anxiety and antidepressant pharmacotherapy with severity of histological features in patients with NAFLD. Methods: We analysed 567 patients with biopsy-proven NAFLD enrolled in the Duke NAFLD Clinical Database. Depressive and anxiety symptoms were assessed using the Hospital Anxiety & Depression Scale (HADS). The associations of depression and anxiety with severity of histological features of NAFLD were analysed using multiple logistic (or ordinal logistic) regression models with and without adjusting for confounding factors. Result: Subclinical and clinical depression was noted in 53% and 14% of patients respectively. Subclinical and clinical anxiety was noted in 45% and 25% of patients respectively. After adjusting for confounders, depression was significantly associated with more severe hepatocyte ballooning in a dose-dependent manner (likelihood ratio test, P = 0.0201); adjusted cumulative odds ratio (COR) of subclinical and clinical depression for having a higher grade of hepatocyte ballooning were 2.1 [95% CI, 1.0, 4.4] and 3.6 [95% CI, 1.4, 8.8]. Conclusions: In patients with NAFLD, depression was associated with more severe hepatocyte ballooning. Further investigation exploring pathobiological mechanisms underlying the observed associations and potential effects of antidepressant pharmacotherapy on NAFLD liver histology is warranted.

Original languageEnglish (US)
Pages (from-to)1062-1070
Number of pages9
JournalLiver International
Volume33
Issue number7
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

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Antidepressive Agents
Anxiety
Depression
Hepatocytes
Logistic Models
Non-alcoholic Fatty Liver Disease
Drug Therapy
Histology
Odds Ratio
Databases
Biopsy
Liver

Keywords

  • Hepatic fibrosis
  • Hepatocyte ballooning
  • Liver injury
  • Mood disorder
  • Nonalcoholic steatohepatitis

ASJC Scopus subject areas

  • Hepatology

Cite this

Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease. / Youssef, Nagy Adel; Abdelmalek, Manal F.; Binks, Martin; Guy, Cynthia D.; Omenetti, Alessia; Smith, Alastair D.; Diehl, Anna Mae E.; Suzuki, Ayako.

In: Liver International, Vol. 33, No. 7, 01.08.2013, p. 1062-1070.

Research output: Contribution to journalArticle

Youssef, NA, Abdelmalek, MF, Binks, M, Guy, CD, Omenetti, A, Smith, AD, Diehl, AME & Suzuki, A 2013, 'Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease', Liver International, vol. 33, no. 7, pp. 1062-1070. https://doi.org/10.1111/liv.12165
Youssef, Nagy Adel ; Abdelmalek, Manal F. ; Binks, Martin ; Guy, Cynthia D. ; Omenetti, Alessia ; Smith, Alastair D. ; Diehl, Anna Mae E. ; Suzuki, Ayako. / Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease. In: Liver International. 2013 ; Vol. 33, No. 7. pp. 1062-1070.
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AU - Abdelmalek, Manal F.

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AU - Guy, Cynthia D.

AU - Omenetti, Alessia

AU - Smith, Alastair D.

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AU - Suzuki, Ayako

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