Asymptotic hippocampal long-term potentiation in rats does not preclude additional potentiation at later phases

Julietta Uta Frey, K. Schollmeier, K. G. Reymann, T. Seidenbecher

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Hippocampal long-term potentiation may serve as an elementary process underlying certain forms of learning and memory in vertebrates. As is the case with behavioural memory, hippocampal long-term potentiation in the CA1 region and in the dentate gyrus exhibits distinct phases. These comprise a short-term early potentiation which lasts one to three hours and is independent of protein synthesis and is characterized in general by the activation of N-methyl-d-aspartate receptors and protein kinases; and a later, longer lasting phase, which can be separated by inhibitors of protein synthesis. Here, we report that the prior induction of long-term potentiation, both in the dentate gyrus in vivo and in the CA1-region in vitro, precludes further long-term but not short-term potentiation by means of a newly delivered conditioning stimulus to a subset of the same activated synapse population during the early stage (∼ 1-3 hours post tetanus). In contrast, a subsequent, long-lasting potentiation can be induced after the establishment of the late phase of potentiation (> 4 h). Thus, the system preserves the capacity for short-term potentiation immediately after potentiation, but the capacity for the induction of longer lasting plastic changes is recovered only after about four hours. Our results demonstrate that, once long-term potentiation has been established, hippocampal neurons do not lose their capacity for functional plasticity during certain phases of the maintenance of long-term potentiation.

Original languageEnglish (US)
Pages (from-to)799-807
Number of pages9
JournalNeuroscience
Volume67
Issue number4
DOIs
StatePublished - Jan 1 1995

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Long-Term Potentiation
Dentate Gyrus
Aspartate Kinase
Protein Synthesis Inhibitors
Tetanus
Synapses
Protein Kinases
Vertebrates
Learning
Neurons
Population
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Asymptotic hippocampal long-term potentiation in rats does not preclude additional potentiation at later phases. / Frey, Julietta Uta; Schollmeier, K.; Reymann, K. G.; Seidenbecher, T.

In: Neuroscience, Vol. 67, No. 4, 01.01.1995, p. 799-807.

Research output: Contribution to journalArticle

Frey, Julietta Uta ; Schollmeier, K. ; Reymann, K. G. ; Seidenbecher, T. / Asymptotic hippocampal long-term potentiation in rats does not preclude additional potentiation at later phases. In: Neuroscience. 1995 ; Vol. 67, No. 4. pp. 799-807.
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