ATAD3A on the path to cancer

Yong Teng, Liwei Lang, Chloe Shay

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The ATPase family AAA-domain containing protein 3A (ATAD3A), a nuclear-encoded mitochondrial enzyme, is involved in diverse cellular processes, including mitochondrial dynamics, cell death and cholesterol metabolism. Overexpression and/or mutation of the ATAD3A gene have been observed in different types of cancer, associated with cancer development and progression. The dysregulated ATAD3A acts as a broker of a mitochondria-endoplasmic reticulum connection in cancer cells, and inhibition of this enzyme leads to tumor repression and enhanced sensitivity to chemotherapy and radiation. As such, ATAD3A is a promising drug target in cancer treatment.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages259-269
Number of pages11
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1134
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Adenosine Triphosphatases
Neoplasms
Proteins
Mitochondria
Oncology
Chemotherapy
Mitochondrial Dynamics
Cell death
Enzymes
Metabolism
Tumors
Genes
Endoplasmic Reticulum
Cholesterol
Cells
Radiation
Cell Death
Protein Domains
Drug Therapy
Mutation

Keywords

  • ATAD3A
  • Cancer treatment
  • Drug target
  • Mitochondria
  • Oncogene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Teng, Y., Lang, L., & Shay, C. (2019). ATAD3A on the path to cancer. In Advances in Experimental Medicine and Biology (pp. 259-269). (Advances in Experimental Medicine and Biology; Vol. 1134). Springer New York LLC. https://doi.org/10.1007/978-3-030-12668-1_14

ATAD3A on the path to cancer. / Teng, Yong; Lang, Liwei; Shay, Chloe.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. p. 259-269 (Advances in Experimental Medicine and Biology; Vol. 1134).

Research output: Chapter in Book/Report/Conference proceedingChapter

Teng, Y, Lang, L & Shay, C 2019, ATAD3A on the path to cancer. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1134, Springer New York LLC, pp. 259-269. https://doi.org/10.1007/978-3-030-12668-1_14
Teng Y, Lang L, Shay C. ATAD3A on the path to cancer. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2019. p. 259-269. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-030-12668-1_14
Teng, Yong ; Lang, Liwei ; Shay, Chloe. / ATAD3A on the path to cancer. Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. pp. 259-269 (Advances in Experimental Medicine and Biology).
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