ATAD3A on the path to cancer

Yong Teng, Liwei Lang, Chloe Shay

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The ATPase family AAA-domain containing protein 3A (ATAD3A), a nuclear-encoded mitochondrial enzyme, is involved in diverse cellular processes, including mitochondrial dynamics, cell death and cholesterol metabolism. Overexpression and/or mutation of the ATAD3A gene have been observed in different types of cancer, associated with cancer development and progression. The dysregulated ATAD3A acts as a broker of a mitochondria-endoplasmic reticulum connection in cancer cells, and inhibition of this enzyme leads to tumor repression and enhanced sensitivity to chemotherapy and radiation. As such, ATAD3A is a promising drug target in cancer treatment.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages259-269
Number of pages11
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1134
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • ATAD3A
  • Cancer treatment
  • Drug target
  • Mitochondria
  • Oncogene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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