Atherosclerosis and restenosis: Is there a role for RAGE?

Peter Nawroth, Angelika Bierhaus, Mario Marrero, Hiroshi Yamamoto, David M. Stern

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Diabetic vascular complications are a major cause of morbidity and mortality. Furthermore, such vascular disease is only incompletely explained by "traditional" risk factors in the nondiabetic complications. This situation has prompted the search for factors contributing to the pathogenesis of accelerated and more severe vascular disease in patients with diabetes. We review evidence that receptor for advanced glycation end products (RAGE), via its interaction with ligands, serves as a cofactor exacerbating diabetic vascular disease. RAGE is a member of the immunoglobulin superfamily of cell surface molecules with a diverse repertoire of ligands reminiscent of pattern recognition receptors. In the diabetic milieu, two classes of RAGE ligands, products of nonenzymatic glycoxidation and S100 proteins, appear to drive receptor-mediated cellular activation and, potentially, acceleration of vascular disease.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalCurrent Diabetes Reports
Volume5
Issue number1
DOIs
StatePublished - Feb 2005

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Nawroth, P., Bierhaus, A., Marrero, M., Yamamoto, H., & Stern, D. M. (2005). Atherosclerosis and restenosis: Is there a role for RAGE? Current Diabetes Reports, 5(1), 11-16. https://doi.org/10.1007/s11892-005-0061-9