Atrial natriuretic peptide differentially modulates T- and L-type calcium channels

R. T. McCarthy, Carlos M Isales, Wendy B Bollag, H. Rasmussen, P. Q. Barrett

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Atrial natriuretic peptide (ANP) inhibits the secretion of aldosterone stimulated by any of these major physiological agonists: angiotensin II, adrenocorticotropic hormone, or K+. The stimulatory actions of each of these agonists depend on calcium influx through voltage-dependent calcium channels. Because two types of calcium channels have been previously described in bovine glomerulosa cells (T- and L-type), the patch-clamp technique was used to evaluate the effect of ANP on each voltage-dependent calcium channel type. ANP was found to differentially modulate these two channel types, stimulating L-current while inhibiting T-current. Inhibition of T-current resulted from a shift in the voltage dependence of inactivation to more negative potentials within the physiological range. These results indicate that the ANP-induced inhibition of aldosterone secretion may be partially mediated via a reduction of the calcium current through T-type channels.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume258
Issue number3 27-3
StatePublished - Apr 11 1990

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T-Type Calcium Channels
L-Type Calcium Channels
Atrial Natriuretic Factor
Calcium Channels
Aldosterone
Calcium
Patch-Clamp Techniques
Angiotensin II
Adrenocorticotropic Hormone

Keywords

  • aldosterone secretion

ASJC Scopus subject areas

  • Physiology

Cite this

Atrial natriuretic peptide differentially modulates T- and L-type calcium channels. / McCarthy, R. T.; Isales, Carlos M; Bollag, Wendy B; Rasmussen, H.; Barrett, P. Q.

In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology, Vol. 258, No. 3 27-3, 11.04.1990.

Research output: Contribution to journalArticle

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