Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease

A. Hassan; N. Ali; Y. Dong; N. D. Carter; H. S. Markus

doi:10.1212/WNL.57.9.1726

Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease

A. Hassan, N. Ali, Y. Dong, N. D. Carter, H. S. Markus

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The atrial natriuretic peptide (ANP) gene may underlie stroke susceptibility and sensitivity to cerebral ischemia in an animal model of stroke. The authors investigate its role in humans by genotyping a polymorphism (G664A) in 436 patients with ischemic cerebrovascular disease and 295 community control subjects. The frequency of this variant was similar in both groups and across the different stroke subtypes. The ANP gene G664A polymorphism is therefore unlikely to be an important risk factor for ischemic stroke in this population.

Original language	English (US)
Pages (from-to)	1726-1728
Number of pages	3
Journal	Neurology
Volume	57
Issue number	9
DOIs	https://doi.org/10.1212/WNL.57.9.1726
State	Published - Nov 13 2001
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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abstract = "The atrial natriuretic peptide (ANP) gene may underlie stroke susceptibility and sensitivity to cerebral ischemia in an animal model of stroke. The authors investigate its role in humans by genotyping a polymorphism (G664A) in 436 patients with ischemic cerebrovascular disease and 295 community control subjects. The frequency of this variant was similar in both groups and across the different stroke subtypes. The ANP gene G664A polymorphism is therefore unlikely to be an important risk factor for ischemic stroke in this population.",

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AU - Ali, N.

AU - Dong, Y.

AU - Carter, N. D.

AU - Markus, H. S.

PY - 2001/11/13

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AB - The atrial natriuretic peptide (ANP) gene may underlie stroke susceptibility and sensitivity to cerebral ischemia in an animal model of stroke. The authors investigate its role in humans by genotyping a polymorphism (G664A) in 436 patients with ischemic cerebrovascular disease and 295 community control subjects. The frequency of this variant was similar in both groups and across the different stroke subtypes. The ANP gene G664A polymorphism is therefore unlikely to be an important risk factor for ischemic stroke in this population.

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Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease

Abstract

ASJC Scopus subject areas

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