Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease

A. Hassan, N. Ali, Yanbin Dong, N. D. Carter, H. S. Markus

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The atrial natriuretic peptide (ANP) gene may underlie stroke susceptibility and sensitivity to cerebral ischemia in an animal model of stroke. The authors investigate its role in humans by genotyping a polymorphism (G664A) in 436 patients with ischemic cerebrovascular disease and 295 community control subjects. The frequency of this variant was similar in both groups and across the different stroke subtypes. The ANP gene G664A polymorphism is therefore unlikely to be an important risk factor for ischemic stroke in this population.

Original languageEnglish (US)
Pages (from-to)1726-1728
Number of pages3
JournalNeurology
Volume57
Issue number9
DOIs
StatePublished - Nov 13 2001
Externally publishedYes

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Cerebrovascular Disorders
Atrial Natriuretic Factor
Stroke
Genes
Brain Ischemia
Animal Models
Population

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease. / Hassan, A.; Ali, N.; Dong, Yanbin; Carter, N. D.; Markus, H. S.

In: Neurology, Vol. 57, No. 9, 13.11.2001, p. 1726-1728.

Research output: Contribution to journalArticle

Hassan, A. ; Ali, N. ; Dong, Yanbin ; Carter, N. D. ; Markus, H. S. / Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease. In: Neurology. 2001 ; Vol. 57, No. 9. pp. 1726-1728.
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