Atypical presentations of molar pregnancy

Diagnostic roles of imaging, ß-human chorionic gonadotropin measurement, and p57 immunostaining

Sara A. Mohamed, Ayman Al-Hendy, Sharad A Ghamande, Joanna Chaffin, Paul Christopher Browne

Research output: Contribution to journalArticle

Abstract

In modern practice , the diagnosis of molar pregnancy is made at an early gestational age. The opportunity to diagnose gestational trophoblastic disease (GTD) using sonography alone occurs less frequently. The classic appearance of a snowstorm in the endometrial cavity and bilateral theca lutein cysts still applies to the diagnosis of second-trimester GTD. The diagnosis of first-trimester GTD requires increased clinical suspicion. If the sonographic appearance of the pregnancy is atypical, GTD should be included in the differential diagnosis. Additional nonimaging criteria such as serial quantitative ß-human chorionic gonadotropin levels, pathologic examination, and p57 (cyclin-dependent kinase inhibitor 1C protein) immunostaining can accurately confirm the diagnosis of GTD.

Original languageEnglish (US)
Pages (from-to)643-649
Number of pages7
JournalJournal of Ultrasound in Medicine
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Gestational Trophoblastic Disease
Hydatidiform Mole
Chorionic Gonadotropin
Diagnostic Imaging
Cyclin-Dependent Kinase Inhibitor p57
Cyclin-Dependent Kinase Inhibitor Proteins
Lutein
Second Pregnancy Trimester
First Pregnancy Trimester
Gestational Age
Cysts
Ultrasonography
Differential Diagnosis
Pregnancy

Keywords

  • Molar pregnancy
  • Obstetric ultrasound
  • P57 immunostaining
  • Sonography
  • ß-human chorionic gonadotropin

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Atypical presentations of molar pregnancy : Diagnostic roles of imaging, ß-human chorionic gonadotropin measurement, and p57 immunostaining. / Mohamed, Sara A.; Al-Hendy, Ayman; Ghamande, Sharad A; Chaffin, Joanna; Browne, Paul Christopher.

In: Journal of Ultrasound in Medicine, Vol. 35, No. 3, 01.03.2016, p. 643-649.

Research output: Contribution to journalArticle

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