Atypical presentations of molar pregnancy: Diagnostic roles of imaging, ß-human chorionic gonadotropin measurement, and p57 immunostaining

Sara A. Mohamed, Ayman Al-Hendy, Sharad Ghamande, Joanna Chaffin, Paul Browne

Research output: Contribution to journalArticle

Abstract

In modern practice , the diagnosis of molar pregnancy is made at an early gestational age. The opportunity to diagnose gestational trophoblastic disease (GTD) using sonography alone occurs less frequently. The classic appearance of a snowstorm in the endometrial cavity and bilateral theca lutein cysts still applies to the diagnosis of second-trimester GTD. The diagnosis of first-trimester GTD requires increased clinical suspicion. If the sonographic appearance of the pregnancy is atypical, GTD should be included in the differential diagnosis. Additional nonimaging criteria such as serial quantitative ß-human chorionic gonadotropin levels, pathologic examination, and p57 (cyclin-dependent kinase inhibitor 1C protein) immunostaining can accurately confirm the diagnosis of GTD.

Original languageEnglish (US)
Pages (from-to)643-649
Number of pages7
JournalJournal of Ultrasound in Medicine
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • Molar pregnancy
  • Obstetric ultrasound
  • P57 immunostaining
  • Sonography
  • ß-human chorionic gonadotropin

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Atypical presentations of molar pregnancy: Diagnostic roles of imaging, ß-human chorionic gonadotropin measurement, and p57 immunostaining'. Together they form a unique fingerprint.

  • Cite this