Abstract
Sera from patients with Graves’ disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin‐layer chromatography (HPTLC) immunostaining and ELISA. Human monoclonal antibodies (MoAbs) have been prepared by fusion of human myeloma with peripheral lymphocytes from patients with Graves’ disease. A MoAb, TRMo‐4, reacted strongly and specifically with Gb5. These results suggest that anti‐Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. The detection of anti‐Forssman glycolipid antibody may provide a useful means for clinical diagnosis and therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 483-488 |
| Number of pages | 6 |
| Journal | Clinical & Experimental Immunology |
| Volume | 86 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1991 |
| Externally published | Yes |
Keywords
- Forssman glycolipid
- Graves' disease
- Hashimoto's disease
- autoantibodies
- autoimmune disease
ASJC Scopus subject areas
- General Medicine
