Autoantibodies against Forssman glycolipids in Graves' disease and Hashimoto's thyroiditis

T. ARIGA, T. YOSHIDA, T. MIMORI, R. K. YU

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Sera from patients with Graves’ disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin‐layer chromatography (HPTLC) immunostaining and ELISA. Human monoclonal antibodies (MoAbs) have been prepared by fusion of human myeloma with peripheral lymphocytes from patients with Graves’ disease. A MoAb, TRMo‐4, reacted strongly and specifically with Gb5. These results suggest that anti‐Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. The detection of anti‐Forssman glycolipid antibody may provide a useful means for clinical diagnosis and therapy.

Original languageEnglish (US)
Pages (from-to)483-488
Number of pages6
JournalClinical & Experimental Immunology
Volume86
Issue number3
DOIs
StatePublished - Dec 1991

Keywords

  • Forssman glycolipid
  • Graves' disease
  • Hashimoto's disease
  • autoantibodies
  • autoimmune disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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