Autoimmune mechanisms in peripheral neuropathies

Robert K Yu, Toshio Ariga, Tatsuo Kohriyama, Susumu Kusunoki, Yasuhiro Maeda, Nobuyuki Miyatani

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

In certain patients with demyelinating neuropathy and plasma cell dyscrasia, there are IgM monoclonal antibodies that recognize a carbohydrate epitope shared by myelin‐associated glycoprotein (MAG) and at least two acidic glycolipids in the peripheral nervous system (PNS). The structures of the two acidic lipids have been elucidated as a new class of glycosphingolipids, termed sulfoglucuronyl glycolipids (SGGLs). SGGLs have been demonstrated to be present in myelin, axolemma, and other glia‐related membranes in PNS of several animal species, as well as in human dorsal root ganglia and sympathetic ganglia. In rabbits sensitized with sulfoglucuronyl paragloboside (SGPG), a major SGGL in PNS, antibodies developed with reactivities toward SGPG and MAG. The animals also showed moderate weakness, a slowed nerve conduction velocity, and evidence of conduction block. Recently we also found SGPG in rat brain microvessels. This finding supports our hypothesis that autoantibodies may first interact with endothelial cell‐bound antigens and that this might change the permeability of the blood‐brain or blood‐nerve barrier to permit the entry of these autoantibodies into the nervous system. Our data are consistent with the concept that an autoimmune response against the sulfoglucuronyl residue may participate in the pathogenesis of immune‐mediated neuropathy.

Original languageEnglish (US)
Pages (from-to)S30-S35
JournalAnnals of Neurology
Volume27
Issue number1 S
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Glycolipids
Peripheral Nervous System Diseases
Peripheral Nervous System
Autoantibodies
Glycoproteins
Glycosphingolipids
Sympathetic Ganglia
Paraproteinemias
Neural Conduction
Spinal Ganglia
Myelin Sheath
Microvessels
Autoimmunity
Nervous System
Immunoglobulin M
Epitopes
Permeability
Monoclonal Antibodies
Carbohydrates
Rabbits

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Yu, R. K., Ariga, T., Kohriyama, T., Kusunoki, S., Maeda, Y., & Miyatani, N. (1990). Autoimmune mechanisms in peripheral neuropathies. Annals of Neurology, 27(1 S), S30-S35. https://doi.org/10.1002/ana.410270709

Autoimmune mechanisms in peripheral neuropathies. / Yu, Robert K; Ariga, Toshio; Kohriyama, Tatsuo; Kusunoki, Susumu; Maeda, Yasuhiro; Miyatani, Nobuyuki.

In: Annals of Neurology, Vol. 27, No. 1 S, 01.01.1990, p. S30-S35.

Research output: Contribution to journalArticle

Yu, RK, Ariga, T, Kohriyama, T, Kusunoki, S, Maeda, Y & Miyatani, N 1990, 'Autoimmune mechanisms in peripheral neuropathies', Annals of Neurology, vol. 27, no. 1 S, pp. S30-S35. https://doi.org/10.1002/ana.410270709
Yu RK, Ariga T, Kohriyama T, Kusunoki S, Maeda Y, Miyatani N. Autoimmune mechanisms in peripheral neuropathies. Annals of Neurology. 1990 Jan 1;27(1 S):S30-S35. https://doi.org/10.1002/ana.410270709
Yu, Robert K ; Ariga, Toshio ; Kohriyama, Tatsuo ; Kusunoki, Susumu ; Maeda, Yasuhiro ; Miyatani, Nobuyuki. / Autoimmune mechanisms in peripheral neuropathies. In: Annals of Neurology. 1990 ; Vol. 27, No. 1 S. pp. S30-S35.
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