Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease

D. Ramirez-Montealegre, S. Chattopadhyay, T. M. Curran, C. Wasserfall, L. Pritchard, D. Schatz, J. Petitto, D. Hopkins, Jin-Xiong She, P. G. Rothberg, M. Atkinson, David A. Pearce

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The pathogenic mechanisms underlying Batten disease are unclear. Patients uniformly possess autoantibodies against glutamic acid decarboxylase (GAD) that are predominantly reactive with a region of GAD (amino acids 1 to 20) distinct from subjects with autoimmune type 1 diabetes or stiff-person syndrome. Batten patients did not possess autoantibodies against other type 1 diabetes-associated autoantigens and human leukocyte antigen genotypes revealed no specific associations with this disease.

Original languageEnglish (US)
Pages (from-to)743-745
Number of pages3
JournalNeurology
Volume64
Issue number4
DOIs
StatePublished - Feb 22 2005

Fingerprint

Neuronal Ceroid-Lipofuscinoses
Glutamate Decarboxylase
Autoimmunity
Type 1 Diabetes Mellitus
Neurodegenerative Diseases
Autoantibodies
Stiff-Person Syndrome
Autoantigens
HLA Antigens
Genotype
Amino Acids

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Ramirez-Montealegre, D., Chattopadhyay, S., Curran, T. M., Wasserfall, C., Pritchard, L., Schatz, D., ... Pearce, D. A. (2005). Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease. Neurology, 64(4), 743-745. https://doi.org/10.1212/01.WNL.0000151973.08426.7E

Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease. / Ramirez-Montealegre, D.; Chattopadhyay, S.; Curran, T. M.; Wasserfall, C.; Pritchard, L.; Schatz, D.; Petitto, J.; Hopkins, D.; She, Jin-Xiong; Rothberg, P. G.; Atkinson, M.; Pearce, David A.

In: Neurology, Vol. 64, No. 4, 22.02.2005, p. 743-745.

Research output: Contribution to journalArticle

Ramirez-Montealegre, D, Chattopadhyay, S, Curran, TM, Wasserfall, C, Pritchard, L, Schatz, D, Petitto, J, Hopkins, D, She, J-X, Rothberg, PG, Atkinson, M & Pearce, DA 2005, 'Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease', Neurology, vol. 64, no. 4, pp. 743-745. https://doi.org/10.1212/01.WNL.0000151973.08426.7E
Ramirez-Montealegre D, Chattopadhyay S, Curran TM, Wasserfall C, Pritchard L, Schatz D et al. Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease. Neurology. 2005 Feb 22;64(4):743-745. https://doi.org/10.1212/01.WNL.0000151973.08426.7E
Ramirez-Montealegre, D. ; Chattopadhyay, S. ; Curran, T. M. ; Wasserfall, C. ; Pritchard, L. ; Schatz, D. ; Petitto, J. ; Hopkins, D. ; She, Jin-Xiong ; Rothberg, P. G. ; Atkinson, M. ; Pearce, David A. / Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease. In: Neurology. 2005 ; Vol. 64, No. 4. pp. 743-745.
@article{0b112e9ddf1b4ed0ad7fc6b13090f9c7,
title = "Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease",
abstract = "The pathogenic mechanisms underlying Batten disease are unclear. Patients uniformly possess autoantibodies against glutamic acid decarboxylase (GAD) that are predominantly reactive with a region of GAD (amino acids 1 to 20) distinct from subjects with autoimmune type 1 diabetes or stiff-person syndrome. Batten patients did not possess autoantibodies against other type 1 diabetes-associated autoantigens and human leukocyte antigen genotypes revealed no specific associations with this disease.",
author = "D. Ramirez-Montealegre and S. Chattopadhyay and Curran, {T. M.} and C. Wasserfall and L. Pritchard and D. Schatz and J. Petitto and D. Hopkins and Jin-Xiong She and Rothberg, {P. G.} and M. Atkinson and Pearce, {David A.}",
year = "2005",
month = "2",
day = "22",
doi = "10.1212/01.WNL.0000151973.08426.7E",
language = "English (US)",
volume = "64",
pages = "743--745",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease

AU - Ramirez-Montealegre, D.

AU - Chattopadhyay, S.

AU - Curran, T. M.

AU - Wasserfall, C.

AU - Pritchard, L.

AU - Schatz, D.

AU - Petitto, J.

AU - Hopkins, D.

AU - She, Jin-Xiong

AU - Rothberg, P. G.

AU - Atkinson, M.

AU - Pearce, David A.

PY - 2005/2/22

Y1 - 2005/2/22

N2 - The pathogenic mechanisms underlying Batten disease are unclear. Patients uniformly possess autoantibodies against glutamic acid decarboxylase (GAD) that are predominantly reactive with a region of GAD (amino acids 1 to 20) distinct from subjects with autoimmune type 1 diabetes or stiff-person syndrome. Batten patients did not possess autoantibodies against other type 1 diabetes-associated autoantigens and human leukocyte antigen genotypes revealed no specific associations with this disease.

AB - The pathogenic mechanisms underlying Batten disease are unclear. Patients uniformly possess autoantibodies against glutamic acid decarboxylase (GAD) that are predominantly reactive with a region of GAD (amino acids 1 to 20) distinct from subjects with autoimmune type 1 diabetes or stiff-person syndrome. Batten patients did not possess autoantibodies against other type 1 diabetes-associated autoantigens and human leukocyte antigen genotypes revealed no specific associations with this disease.

UR - http://www.scopus.com/inward/record.url?scp=13844319713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844319713&partnerID=8YFLogxK

U2 - 10.1212/01.WNL.0000151973.08426.7E

DO - 10.1212/01.WNL.0000151973.08426.7E

M3 - Article

C2 - 15728308

AN - SCOPUS:13844319713

VL - 64

SP - 743

EP - 745

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -