Autologous mesenchymal stem cells for post-ischemic myocardial repair.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Cell transplantation is a novel therapy for patients with postinfarction ventricular dysfunction and congestive heart failure. The potential of mesenchymal stem cells (MSCs) to be used in the injured myocardium is unlimited because of their ability to self-renew and differentiate into cardiomyocytes in vitro and in vivo. In addition, MSCs are easy to harvest and have a high proliferation capability. Finally, autologous MSCs can survive permanently and integrate with healthy host tissue to form new myocardium after implantation in vivo. We have used autologous cultured MSCs grafts for mouse and rat myocardial infarction in more than 500 cases. From these grafting experiments, it has been shown that cultured autologous MSCs grafting is a useful approach in the treatment of ischemic heart failure. This chapter offers a step-by-step guide for successful research on cultured MSCs for the treatment of myocardial infarction, as well as a set of techniques for evaluating postimplantation myocardial repair.

Original languageEnglish (US)
Pages (from-to)183-192
Number of pages10
JournalMethods in molecular medicine
Volume112
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Mesenchymal Stromal Cells
Myocardium
Heart Failure
Myocardial Infarction
Ventricular Dysfunction
Cell Transplantation
Cardiac Myocytes
Therapeutics
Transplants
Research

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Autologous mesenchymal stem cells for post-ischemic myocardial repair. / Tang, Yao Liang.

In: Methods in molecular medicine, Vol. 112, 01.01.2005, p. 183-192.

Research output: Contribution to journalReview article

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