Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison

Medicine & Life Sciences

• 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester 100%
• Pyrroles 65%
• Autophagic Cell Death 61%
• Polyploidy 53%
• Cellular Senescence 46%
• Microtubules 41%
• Poisons 31%
• Breast Neoplasms 27%
• MCF-7 Cells 17%
• In Situ Nick-End Labeling 11%
• Apoptosis 9%
• Caspase 3 9%
• Cell Line 9%
• Galactosidases 8%
• Gentian Violet 7%
• Staining and Labeling 6%
• Acridine Orange 6%
• Population 6%
• Vacuoles 5%
• Multiple Drug Resistance 5%
• Polymerization 5%
• Tumor Cell Line 5%
• Autophagy 5%
• Coloring Agents 4%
• Cell Cycle 4%
• Flow Cytometry 4%
• Cell Survival 4%
• Cell Death 4%
• Growth 2%
• Pharmaceutical Preparations 2%
• Neoplasms 1%

Chemical Compounds

• Poison 49%
• Cell Death 45%
• Pyrrole 39%
• Cytometry 29%
• Proliferative 18%
• Acridine Orange 18%
• Growth Inhibition 16%
• Crystal Violet 16%
• Pyrroles 16%
• Antiproliferative 14%
• Cell Viability 14%
• Pump 13%
• Flow 9%
• Resistance 8%
• Dye 8%
• Polymerization Reaction 8%
• Drug 7%