Axon regeneration through blood vessel allografts after cyclosporine treatment.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The present study describes the usefulness of blood vessel allografts to repair gaps in rat peripheral nerve after immunosuppression with cyclosporine. Isogeneic strains of rats with known histoincompatibility were used for this study. A 10-mm gap was created in the peroneal nerve of host Fischer rats. The gap was bridged by a 12-mm section of internal carotid artery removed from a Buffalo strain of rat. The host rats were divided into two groups. One group received no immunosuppression, whereas the other group was treated with cyclosporine. Untreated control rats immunologically rejected the allografted vessels and were unable to support host axonal regeneration through them. On the other hand, in cyclosporine-treated rats the allografted vessels survived. The regenerating host axons reorganized to form a functional nerve within the vessel conduit. The regenerated axons persisted even after rejection of the allografted vessel caused by cessation of immunotherapy. These results show that blood vessel allografts can serve as an effective conduit for reorganization of regenerated nerves and can bridge gaps in peripheral nerves.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalJournal of neurosurgery
Volume70
Issue number1
DOIs
StatePublished - Jan 1 1989

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Cyclosporine
Allografts
Blood Vessels
Axons
Regeneration
Peripheral Nerves
Immunosuppression
Therapeutics
Peroneal Nerve
Buffaloes
Inbred F344 Rats
Internal Carotid Artery
Immunotherapy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Axon regeneration through blood vessel allografts after cyclosporine treatment. / Gulati, Adarsh K.

In: Journal of neurosurgery, Vol. 70, No. 1, 01.01.1989, p. 115-120.

Research output: Contribution to journalArticle

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