B Cell Disorders in Children: Part II

Dixie D. Griffin, William K. Dolen

Research output: Contribution to journalReview article

Abstract

Purpose of Review: B cell disorders result in decreased levels or function of immunoglobulins in an individual. Genetic mutations have been reported in a variety of B cell disorders. This review, in follow-up to a previous review, describes some rare B cell disorders as well as their known underlying genetic etiologies. Recent Findings: Genetic studies identify and permit precise classification of an increasing number of B cell disorders, leading to a greater understanding of B cell development and function. Summary: The B cell disorders are rare diseases. While clinicians are most familiar with X-linked agammaglobulinemia and so-called common variable immunodeficiency (CVID), there are many causes of hypogammaglobulinemia. Genetic testing provides a specific diagnosis, offers useful information for genetic counseling, and can identify previously unrecognized B cell disorders.

Original languageEnglish (US)
Article number64
JournalCurrent Allergy and Asthma Reports
Volume20
Issue number11
DOIs
StatePublished - Nov 1 2020

Keywords

  • Antibody deficiency
  • APDS
  • B cell disorders
  • BLK
  • CTLA-4
  • Good syndrome
  • Hyper IgM syndrome
  • IgG subclass deficiency
  • Kabuki syndrome
  • Selective IgA deficiency
  • Specific antibody deficiency
  • TWEAK

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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