Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+

Nevin A Lambert, Neil L. Harrison, Timothy J. Teyler

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The mechanism of disinhibition produced by (±)-baclofen was studied using intracellular recording in area CA1 of rat hippocampal slices. Baclofen reversibly depressed monosynaptic IPSPs evoked by direct activation of interneurons in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and d,l-2amino-5-phosphonovalerate (APV). Ba2+ prevented baclofen-induced hyperpolarization of pyramidal neurons but not depression of monosynaptic IPSPs by baclofen. Baclofen reversibly depressed monosynaptic IPSPs when applied close to the recording site, but was ineffective when applied close to the stimulating site in stratum radiatum. These results suggest that baclofen disinhibits pyramidal neurons in area CA1 of the rat hippocampus by activating receptors on the terminals of inhibitory neurons that are coupled to a Ba2+-insensitive effector mechanism.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalBrain Research
Volume547
Issue number2
DOIs
StatePublished - May 3 1991
Externally publishedYes

Fingerprint

Baclofen
Hippocampus
Inhibitory Postsynaptic Potentials
Pyramidal Cells
Excitatory Amino Acid Antagonists
Glutamate Receptors
Interneurons
Neurons

Keywords

  • CGP 35348
  • GABA receptor
  • Inhibitory neuron
  • Interneuron

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+ . / Lambert, Nevin A; Harrison, Neil L.; Teyler, Timothy J.

In: Brain Research, Vol. 547, No. 2, 03.05.1991, p. 349-352.

Research output: Contribution to journalArticle

Lambert, Nevin A ; Harrison, Neil L. ; Teyler, Timothy J. / Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+ In: Brain Research. 1991 ; Vol. 547, No. 2. pp. 349-352.
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