Bacteremia and skin/bone infections in two patients with X-linked agammaglobulinemia caused by an unusual organism related to Flexispira/Helicobacter species

Brenda Cuccherini, Kevin Chua, Vee Gill, Susan Weir, Betty Beasley Wray, Donn Stewart, David Nelson, Ivan Fuss, Warren Strober

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Two patients with Bruton's X-linked agammaglobulinemia are described with bacteremia and skin/bone infection due to an organism which by 16S rRNA gene sequence analysis was most closely related to 'Flexispira' rappini (and thus designated a Flexispira-like organism, FLO) and more distantly related to the Helicobacter species. The organism required microaerobic conditions and, supplemental H2 gas for growth and was reliably stained with acridine orange. In common with Helicobacter cinaedi infections, the focus of the FLO infection was in one case in the blood vessels or lymphatics of an extremity and in the other case in the skin and adjacent bone of an extremity. In both cases, prolonged IV antibiotic therapy was necessary to clear the infection. The susceptibility of XLA patients to FLO infection appears to be related to the fact that XLA is associated with severe B cell (humoral) immunodeficiency and thus these patients have difficulty with intravascular or intralymphatic infection. These findings elucidate the nature of FLO infections in humans and point the way to their detection and treatment. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalClinical Immunology
Volume97
Issue number2
DOIs
StatePublished - Jan 1 2000

Fingerprint

Helicobacter
Bacteremia
Bone and Bones
Skin
Infection
Extremities
Acridine Orange
Helicobacter Infections
rRNA Genes
Sequence Analysis
Blood Vessels
Bruton type agammaglobulinemia
B-Lymphocytes
Gases
Anti-Bacterial Agents
Therapeutics
Growth

Keywords

  • Agammaglobulinemia
  • Bacteremia
  • Helicobacter
  • Immunodeficiency

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Bacteremia and skin/bone infections in two patients with X-linked agammaglobulinemia caused by an unusual organism related to Flexispira/Helicobacter species. / Cuccherini, Brenda; Chua, Kevin; Gill, Vee; Weir, Susan; Wray, Betty Beasley; Stewart, Donn; Nelson, David; Fuss, Ivan; Strober, Warren.

In: Clinical Immunology, Vol. 97, No. 2, 01.01.2000, p. 121-129.

Research output: Contribution to journalArticle

Cuccherini, Brenda ; Chua, Kevin ; Gill, Vee ; Weir, Susan ; Wray, Betty Beasley ; Stewart, Donn ; Nelson, David ; Fuss, Ivan ; Strober, Warren. / Bacteremia and skin/bone infections in two patients with X-linked agammaglobulinemia caused by an unusual organism related to Flexispira/Helicobacter species. In: Clinical Immunology. 2000 ; Vol. 97, No. 2. pp. 121-129.
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