Basal ganglia T2 relaxation times in schizophrenia: a quantitative magnetic resonance imaging study in relation to tardive dyskinesia

Peter F Buckley, Eadbhard O'Callaghan, Fiona Mulvany, Conall Larkin, John P. Stacks, Oonagh Redmond, Joseph T. Ennis, Paul Thompson, John L. Waddington

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Transverse, or spin-spin, relaxation times (T2) from magnetic resonance images of basal ganglia structures were compared between control subjects and patients with schizophrenia, who were subdivided on the basis of the presence or absence of tardive dyskinesia. As a group, schizophrenic patients showed evidence of somewhat more prolonged T2 relaxation times in the right putamen and globus pallidus than did control subjects; there were no significant correlations between hemispheric T2 values and corresponding volumes of the lateral ventricles. Overall, there was little difference in T2 values between patients with and without tardive dyskinesia. These data extend the range of evidence for basal ganglia dysfunction in schizophrenia, but they do not support earlier reports of prominent T2 changes associated with tardive dyskinesia.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalPsychiatry Research: Neuroimaging
Volume61
Issue number2
DOIs
StatePublished - Aug 8 1995

Fingerprint

Basal Ganglia
Schizophrenia
Magnetic Resonance Imaging
Globus Pallidus
Lateral Ventricles
Putamen
Magnetic Resonance Spectroscopy
Tardive Dyskinesia

Keywords

  • Globus pallidus
  • Movement disorder
  • Neuroleptic side effects
  • Putamen

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Basal ganglia T2 relaxation times in schizophrenia : a quantitative magnetic resonance imaging study in relation to tardive dyskinesia. / Buckley, Peter F; O'Callaghan, Eadbhard; Mulvany, Fiona; Larkin, Conall; Stacks, John P.; Redmond, Oonagh; Ennis, Joseph T.; Thompson, Paul; Waddington, John L.

In: Psychiatry Research: Neuroimaging, Vol. 61, No. 2, 08.08.1995, p. 95-102.

Research output: Contribution to journalArticle

Buckley, PF, O'Callaghan, E, Mulvany, F, Larkin, C, Stacks, JP, Redmond, O, Ennis, JT, Thompson, P & Waddington, JL 1995, 'Basal ganglia T2 relaxation times in schizophrenia: a quantitative magnetic resonance imaging study in relation to tardive dyskinesia', Psychiatry Research: Neuroimaging, vol. 61, no. 2, pp. 95-102. https://doi.org/10.1016/0925-4927(95)02591-K
Buckley, Peter F ; O'Callaghan, Eadbhard ; Mulvany, Fiona ; Larkin, Conall ; Stacks, John P. ; Redmond, Oonagh ; Ennis, Joseph T. ; Thompson, Paul ; Waddington, John L. / Basal ganglia T2 relaxation times in schizophrenia : a quantitative magnetic resonance imaging study in relation to tardive dyskinesia. In: Psychiatry Research: Neuroimaging. 1995 ; Vol. 61, No. 2. pp. 95-102.
@article{cc0f3eab16c84598869b51ed7bce7588,
title = "Basal ganglia T2 relaxation times in schizophrenia: a quantitative magnetic resonance imaging study in relation to tardive dyskinesia",
abstract = "Transverse, or spin-spin, relaxation times (T2) from magnetic resonance images of basal ganglia structures were compared between control subjects and patients with schizophrenia, who were subdivided on the basis of the presence or absence of tardive dyskinesia. As a group, schizophrenic patients showed evidence of somewhat more prolonged T2 relaxation times in the right putamen and globus pallidus than did control subjects; there were no significant correlations between hemispheric T2 values and corresponding volumes of the lateral ventricles. Overall, there was little difference in T2 values between patients with and without tardive dyskinesia. These data extend the range of evidence for basal ganglia dysfunction in schizophrenia, but they do not support earlier reports of prominent T2 changes associated with tardive dyskinesia.",
keywords = "Globus pallidus, Movement disorder, Neuroleptic side effects, Putamen",
author = "Buckley, {Peter F} and Eadbhard O'Callaghan and Fiona Mulvany and Conall Larkin and Stacks, {John P.} and Oonagh Redmond and Ennis, {Joseph T.} and Paul Thompson and Waddington, {John L.}",
year = "1995",
month = "8",
day = "8",
doi = "10.1016/0925-4927(95)02591-K",
language = "English (US)",
volume = "61",
pages = "95--102",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Basal ganglia T2 relaxation times in schizophrenia

T2 - a quantitative magnetic resonance imaging study in relation to tardive dyskinesia

AU - Buckley, Peter F

AU - O'Callaghan, Eadbhard

AU - Mulvany, Fiona

AU - Larkin, Conall

AU - Stacks, John P.

AU - Redmond, Oonagh

AU - Ennis, Joseph T.

AU - Thompson, Paul

AU - Waddington, John L.

PY - 1995/8/8

Y1 - 1995/8/8

N2 - Transverse, or spin-spin, relaxation times (T2) from magnetic resonance images of basal ganglia structures were compared between control subjects and patients with schizophrenia, who were subdivided on the basis of the presence or absence of tardive dyskinesia. As a group, schizophrenic patients showed evidence of somewhat more prolonged T2 relaxation times in the right putamen and globus pallidus than did control subjects; there were no significant correlations between hemispheric T2 values and corresponding volumes of the lateral ventricles. Overall, there was little difference in T2 values between patients with and without tardive dyskinesia. These data extend the range of evidence for basal ganglia dysfunction in schizophrenia, but they do not support earlier reports of prominent T2 changes associated with tardive dyskinesia.

AB - Transverse, or spin-spin, relaxation times (T2) from magnetic resonance images of basal ganglia structures were compared between control subjects and patients with schizophrenia, who were subdivided on the basis of the presence or absence of tardive dyskinesia. As a group, schizophrenic patients showed evidence of somewhat more prolonged T2 relaxation times in the right putamen and globus pallidus than did control subjects; there were no significant correlations between hemispheric T2 values and corresponding volumes of the lateral ventricles. Overall, there was little difference in T2 values between patients with and without tardive dyskinesia. These data extend the range of evidence for basal ganglia dysfunction in schizophrenia, but they do not support earlier reports of prominent T2 changes associated with tardive dyskinesia.

KW - Globus pallidus

KW - Movement disorder

KW - Neuroleptic side effects

KW - Putamen

UR - http://www.scopus.com/inward/record.url?scp=0028983798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028983798&partnerID=8YFLogxK

U2 - 10.1016/0925-4927(95)02591-K

DO - 10.1016/0925-4927(95)02591-K

M3 - Article

C2 - 7480392

AN - SCOPUS:0028983798

VL - 61

SP - 95

EP - 102

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 2

ER -