Basal ganglia T2 relaxation times in schizophrenia: a quantitative magnetic resonance imaging study in relation to tardive dyskinesia

Peter Buckley, Eadbhard O'Callaghan, Fiona Mulvany, Conall Larkin, John P. Stacks, Oonagh Redmond, Joseph T. Ennis, Paul Thompson, John L. Waddington

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Abstract

Transverse, or spin-spin, relaxation times (T2) from magnetic resonance images of basal ganglia structures were compared between control subjects and patients with schizophrenia, who were subdivided on the basis of the presence or absence of tardive dyskinesia. As a group, schizophrenic patients showed evidence of somewhat more prolonged T2 relaxation times in the right putamen and globus pallidus than did control subjects; there were no significant correlations between hemispheric T2 values and corresponding volumes of the lateral ventricles. Overall, there was little difference in T2 values between patients with and without tardive dyskinesia. These data extend the range of evidence for basal ganglia dysfunction in schizophrenia, but they do not support earlier reports of prominent T2 changes associated with tardive dyskinesia.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalPsychiatry Research: Neuroimaging
Volume61
Issue number2
DOIs
Publication statusPublished - Aug 8 1995

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Keywords

  • Globus pallidus
  • Movement disorder
  • Neuroleptic side effects
  • Putamen

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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