Basement membrane derived inhibitors of angiogenesis

Michael B. Duncan, Raghu Kalluri

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Blood vessel growth during development and disease is likely governed by the balance between pro-and antiangiogenic factors. Numerous reports have focused on the important role of various growth factors during angiogenesis. Peptide fragments derived from basement membranes constitute a relatively new and expanding class of antiangiogenic factors with a potential for clinical relevance. These factors have been studied in a variety of disease models, and genetic evidence for their role in controlling angiogenesis is beginning to be realized. This chapter highlights several of these factors and their mechanism of action as we understand them to date. Gaining additional insight into the full compliment of these antiangiogenic fragments from basement membranes, how they are derived, and their full mechanism of action represents an important challenge in vascular biology today.

Original languageEnglish (US)
Title of host publicationAngiogenesis
Subtitle of host publicationAn Integrative Approach From Science to Medicine
PublisherSpringer US
Pages121-127
Number of pages7
ISBN (Print)9780387715179
DOIs
StatePublished - Dec 1 2008

Fingerprint

Angiogenesis Inhibitors
Basement Membrane
Blood Vessels
Inborn Genetic Diseases
Peptide Fragments
Genetic Models
Growth and Development
Intercellular Signaling Peptides and Proteins

Keywords

  • endostatin
  • tumstatin Vascular basement membranes
  • vascular basement membrane

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Duncan, M. B., & Kalluri, R. (2008). Basement membrane derived inhibitors of angiogenesis. In Angiogenesis: An Integrative Approach From Science to Medicine (pp. 121-127). Springer US. https://doi.org/10.1007/978-0-387-71518-6_11

Basement membrane derived inhibitors of angiogenesis. / Duncan, Michael B.; Kalluri, Raghu.

Angiogenesis: An Integrative Approach From Science to Medicine. Springer US, 2008. p. 121-127.

Research output: Chapter in Book/Report/Conference proceedingChapter

Duncan, MB & Kalluri, R 2008, Basement membrane derived inhibitors of angiogenesis. in Angiogenesis: An Integrative Approach From Science to Medicine. Springer US, pp. 121-127. https://doi.org/10.1007/978-0-387-71518-6_11
Duncan MB, Kalluri R. Basement membrane derived inhibitors of angiogenesis. In Angiogenesis: An Integrative Approach From Science to Medicine. Springer US. 2008. p. 121-127 https://doi.org/10.1007/978-0-387-71518-6_11
Duncan, Michael B. ; Kalluri, Raghu. / Basement membrane derived inhibitors of angiogenesis. Angiogenesis: An Integrative Approach From Science to Medicine. Springer US, 2008. pp. 121-127
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