Basic fibroblast growth factor induces TGF-β release in an isoform and glioma-specific manner

Krishnan Michael Dhandapani, Marlene F. Wade, Virendra B. Mahesh, Darrell W Brann

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aim of the current study was to determine whether basic fibroblast growth factor (bFGF), regulates the release of transforming growth factor-β1 (TGF-β1) from C6 glioma cells. The results of the study show that bFGF (2, 5 and 10 ng/ml) dose dependently induced the release of TGF-β1 from C6 glioma cells, with the 10 ng/ml dose inducing a 2- to 3-fold increase of TGF-β1 levels. This effect was evident as early as 6 h following treatment, with maximal levels observed at 18 h. The effect of bFGF was largely on latent TGF-β1, and was isoform specific, as bFGF had no effect onTGF-β2 release. The bFGF effect on TGF-β1 was also glioma specific, as no such stimulatory effect was observed in rat cortical astrocytes.

Original languageEnglish (US)
Pages (from-to)239-241
Number of pages3
JournalNeuroReport
Volume13
Issue number2
DOIs
StatePublished - Feb 11 2002

Fingerprint

Fibroblast Growth Factor 2
Glioma
Transforming Growth Factors
Protein Isoforms
Fibroblast Growth Factor 5
Fibroblast Growth Factor 10
Astrocytes

Keywords

  • Astrocyte bFGF
  • C6 cells
  • Glioma
  • TGF-β

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Basic fibroblast growth factor induces TGF-β release in an isoform and glioma-specific manner. / Dhandapani, Krishnan Michael; Wade, Marlene F.; Mahesh, Virendra B.; Brann, Darrell W.

In: NeuroReport, Vol. 13, No. 2, 11.02.2002, p. 239-241.

Research output: Contribution to journalArticle

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