Basic fibroblast growth factor induces TGF-β release in an isoform and glioma-specific manner

Krishnan M. Dhandapani, Marlene F. Wade, Virendra B. Mahesh, Darrell W. Brann

Research output: Contribution to journalArticle

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Abstract

The aim of the current study was to determine whether basic fibroblast growth factor (bFGF), regulates the release of transforming growth factor-β1 (TGF-β1) from C6 glioma cells. The results of the study show that bFGF (2, 5 and 10 ng/ml) dose dependently induced the release of TGF-β1 from C6 glioma cells, with the 10 ng/ml dose inducing a 2- to 3-fold increase of TGF-β1 levels. This effect was evident as early as 6 h following treatment, with maximal levels observed at 18 h. The effect of bFGF was largely on latent TGF-β1, and was isoform specific, as bFGF had no effect onTGF-β2 release. The bFGF effect on TGF-β1 was also glioma specific, as no such stimulatory effect was observed in rat cortical astrocytes.

Original languageEnglish (US)
Pages (from-to)239-241
Number of pages3
JournalNeuroReport
Volume13
Issue number2
DOIs
StatePublished - Feb 11 2002

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Keywords

  • Astrocyte bFGF
  • C6 cells
  • Glioma
  • TGF-β

ASJC Scopus subject areas

  • Neuroscience(all)

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