Basolateral amygdala stimulation does not recruit LTP at depotentiated synapses

W. Almaguer-Melian, J. A. Bergado, L. Martínez Martí, C. Duany-Machado, Julietta Uta Frey

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Hippocampal long-term potentiation (LTP) is a long-lasting increase in synaptic efficacy considered to be the cellular basis of memory. LTP consists of an early, protein synthesis-independent phase (E-LTP) and a late phase that depends on protein synthesis (L-LTP). Application of a weak tetanus can induce E-LTP in the dentate gyrus (DG) which can be reinforced into L-LTP by direct stimulation of the basolateral amygdala (BLA) within 30. min before or after LTP induction (structural LTP-reinforcement, [1]). LTP can be depotentiated by low-frequency stimulation (LFS) to the same synaptic input if applied shortly after tetanization (<10. min). Here, we addressed the question of whether stimulation of the BLA is able to recover LTP at depotentiated synaptic inputs. We hypothesized that E-LTP can activate synaptic tags, which were then reset by depotentiation. Stimulation of the BLA thereafter could beneficially act on tag-reactivation as well as on the activation of the synthesis of plasticity-related proteins (PRPs), normally captured by the tags and thus transforming E-LTP into L-LTP. Our results show, that BLA-stimulation was not able to reactivate the resetting of tags by depotentiation in the DG of freely moving rats.

Original languageEnglish (US)
Pages (from-to)549-553
Number of pages5
JournalPhysiology and Behavior
Volume101
Issue number4
DOIs
Publication statusPublished - Nov 1 2010

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Keywords

  • BLA-stimulation
  • Basolateral amygdala
  • Dentate gyrus
  • Depotentiation
  • LTP
  • LTP-reinforcement
  • Long-term potentiation

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Almaguer-Melian, W., Bergado, J. A., Martí, L. M., Duany-Machado, C., & Frey, J. U. (2010). Basolateral amygdala stimulation does not recruit LTP at depotentiated synapses. Physiology and Behavior, 101(4), 549-553. https://doi.org/10.1016/j.physbeh.2010.07.007