Behavioral activation of human hippocampal EEG

Relationship to recent memory

Gregory P Lee, K. J. Meador, D. W. Loring, J. R. Smith, H. F. Flanigin, K. Huh, Anthony M Murro, D. W. King, B. B. Gallagher

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Behaviorally activated EEG was recorded from each hippocampus in 17 epilepsy surgery patients with unilateral (11 left, 6 right) mesial temporal lobe (MTL) seizure onset and correlated with preoperative material-specific memory test performances. Whole-band power (1-30 Hz) was recorded and subjected to spectral analysis under three conditions: (a) eyes closed resting, (b) eyes open with a verbal task, and (c) eyes open with a nonverbal task. Significantly less EEG desynchronization was observed in the epileptogenic hippocampus during the verbal activation condition but not during the eyes-open nonverbal task. Decreased EEG reactivity in the left hippocampus during verbal activation was correlated significantly with verbal memory test impairment among patients with left MTL seizure onset. However, similar relationships were not obtained between right seizure focus patients and performance on a visuospatial learning test. Results confirm the association of left MTL structures with verbal memory functions and emphasize the difficulty in demonstrating a consistent relationship between right MTL structures and visuospatial memory performance.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalJournal of Epilepsy
Volume3
Issue number3
DOIs
StatePublished - Jan 1 1990

Fingerprint

Temporal Lobe
Electroencephalography
Hippocampus
Seizures
Epilepsy
Learning

Keywords

  • Electroencephalography
  • Epilepsy
  • Hippocampus
  • Memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Lee, G. P., Meador, K. J., Loring, D. W., Smith, J. R., Flanigin, H. F., Huh, K., ... Gallagher, B. B. (1990). Behavioral activation of human hippocampal EEG: Relationship to recent memory. Journal of Epilepsy, 3(3), 137-142. https://doi.org/10.1016/0896-6974(90)90099-K

Behavioral activation of human hippocampal EEG : Relationship to recent memory. / Lee, Gregory P; Meador, K. J.; Loring, D. W.; Smith, J. R.; Flanigin, H. F.; Huh, K.; Murro, Anthony M; King, D. W.; Gallagher, B. B.

In: Journal of Epilepsy, Vol. 3, No. 3, 01.01.1990, p. 137-142.

Research output: Contribution to journalArticle

Lee, GP, Meador, KJ, Loring, DW, Smith, JR, Flanigin, HF, Huh, K, Murro, AM, King, DW & Gallagher, BB 1990, 'Behavioral activation of human hippocampal EEG: Relationship to recent memory', Journal of Epilepsy, vol. 3, no. 3, pp. 137-142. https://doi.org/10.1016/0896-6974(90)90099-K
Lee GP, Meador KJ, Loring DW, Smith JR, Flanigin HF, Huh K et al. Behavioral activation of human hippocampal EEG: Relationship to recent memory. Journal of Epilepsy. 1990 Jan 1;3(3):137-142. https://doi.org/10.1016/0896-6974(90)90099-K
Lee, Gregory P ; Meador, K. J. ; Loring, D. W. ; Smith, J. R. ; Flanigin, H. F. ; Huh, K. ; Murro, Anthony M ; King, D. W. ; Gallagher, B. B. / Behavioral activation of human hippocampal EEG : Relationship to recent memory. In: Journal of Epilepsy. 1990 ; Vol. 3, No. 3. pp. 137-142.
@article{3859ff37f6604524b6f2666ac6b7a449,
title = "Behavioral activation of human hippocampal EEG: Relationship to recent memory",
abstract = "Behaviorally activated EEG was recorded from each hippocampus in 17 epilepsy surgery patients with unilateral (11 left, 6 right) mesial temporal lobe (MTL) seizure onset and correlated with preoperative material-specific memory test performances. Whole-band power (1-30 Hz) was recorded and subjected to spectral analysis under three conditions: (a) eyes closed resting, (b) eyes open with a verbal task, and (c) eyes open with a nonverbal task. Significantly less EEG desynchronization was observed in the epileptogenic hippocampus during the verbal activation condition but not during the eyes-open nonverbal task. Decreased EEG reactivity in the left hippocampus during verbal activation was correlated significantly with verbal memory test impairment among patients with left MTL seizure onset. However, similar relationships were not obtained between right seizure focus patients and performance on a visuospatial learning test. Results confirm the association of left MTL structures with verbal memory functions and emphasize the difficulty in demonstrating a consistent relationship between right MTL structures and visuospatial memory performance.",
keywords = "Electroencephalography, Epilepsy, Hippocampus, Memory",
author = "Lee, {Gregory P} and Meador, {K. J.} and Loring, {D. W.} and Smith, {J. R.} and Flanigin, {H. F.} and K. Huh and Murro, {Anthony M} and King, {D. W.} and Gallagher, {B. B.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0896-6974(90)90099-K",
language = "English (US)",
volume = "3",
pages = "137--142",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Behavioral activation of human hippocampal EEG

T2 - Relationship to recent memory

AU - Lee, Gregory P

AU - Meador, K. J.

AU - Loring, D. W.

AU - Smith, J. R.

AU - Flanigin, H. F.

AU - Huh, K.

AU - Murro, Anthony M

AU - King, D. W.

AU - Gallagher, B. B.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Behaviorally activated EEG was recorded from each hippocampus in 17 epilepsy surgery patients with unilateral (11 left, 6 right) mesial temporal lobe (MTL) seizure onset and correlated with preoperative material-specific memory test performances. Whole-band power (1-30 Hz) was recorded and subjected to spectral analysis under three conditions: (a) eyes closed resting, (b) eyes open with a verbal task, and (c) eyes open with a nonverbal task. Significantly less EEG desynchronization was observed in the epileptogenic hippocampus during the verbal activation condition but not during the eyes-open nonverbal task. Decreased EEG reactivity in the left hippocampus during verbal activation was correlated significantly with verbal memory test impairment among patients with left MTL seizure onset. However, similar relationships were not obtained between right seizure focus patients and performance on a visuospatial learning test. Results confirm the association of left MTL structures with verbal memory functions and emphasize the difficulty in demonstrating a consistent relationship between right MTL structures and visuospatial memory performance.

AB - Behaviorally activated EEG was recorded from each hippocampus in 17 epilepsy surgery patients with unilateral (11 left, 6 right) mesial temporal lobe (MTL) seizure onset and correlated with preoperative material-specific memory test performances. Whole-band power (1-30 Hz) was recorded and subjected to spectral analysis under three conditions: (a) eyes closed resting, (b) eyes open with a verbal task, and (c) eyes open with a nonverbal task. Significantly less EEG desynchronization was observed in the epileptogenic hippocampus during the verbal activation condition but not during the eyes-open nonverbal task. Decreased EEG reactivity in the left hippocampus during verbal activation was correlated significantly with verbal memory test impairment among patients with left MTL seizure onset. However, similar relationships were not obtained between right seizure focus patients and performance on a visuospatial learning test. Results confirm the association of left MTL structures with verbal memory functions and emphasize the difficulty in demonstrating a consistent relationship between right MTL structures and visuospatial memory performance.

KW - Electroencephalography

KW - Epilepsy

KW - Hippocampus

KW - Memory

UR - http://www.scopus.com/inward/record.url?scp=0025606825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025606825&partnerID=8YFLogxK

U2 - 10.1016/0896-6974(90)90099-K

DO - 10.1016/0896-6974(90)90099-K

M3 - Article

VL - 3

SP - 137

EP - 142

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 3

ER -