Behavioral, clinical and pathological effects of multiple daily intraperitoneal injections on female mice

Jennifer N. Davis; Cynthia L. Courtney; Hillary Superak; Douglas K. Taylor

doi:10.1038/laban.433

Behavioral, clinical and pathological effects of multiple daily intraperitoneal injections on female mice

Jennifer N. Davis, Cynthia L. Courtney, Hillary Superak, Douglas K. Taylor

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Pharmacological agents are commonly administered to mice through multiple intraperitoneal (i.p.) injections. The i.p. route of administration is usually considered safe, but questions of animal welfare arise when protocols require that multiple injections be given to the same animal. IACUCs must consider the potential risks associated with multiple i.p. injections in order to determine the maximum number of injections an animal can receive within a study protocol, but there are no published studies of such potential risks. The authors investigated the effects of 30 daily i.p. saline injections on the behavior, body condition, weight, fecal corticosterone levels, hematology and pathology of female adult mice. Results indicate that multiple i.p. injections do not cause any ill effects in mice.

Original language	English (US)
Pages (from-to)	131-139
Number of pages	9
Journal	Lab Animal
Volume	43
Issue number	4
DOIs	https://doi.org/10.1038/laban.433
State	Published - Apr 2014
Externally published	Yes

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1038/laban.433

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title = "Behavioral, clinical and pathological effects of multiple daily intraperitoneal injections on female mice",

abstract = "Pharmacological agents are commonly administered to mice through multiple intraperitoneal (i.p.) injections. The i.p. route of administration is usually considered safe, but questions of animal welfare arise when protocols require that multiple injections be given to the same animal. IACUCs must consider the potential risks associated with multiple i.p. injections in order to determine the maximum number of injections an animal can receive within a study protocol, but there are no published studies of such potential risks. The authors investigated the effects of 30 daily i.p. saline injections on the behavior, body condition, weight, fecal corticosterone levels, hematology and pathology of female adult mice. Results indicate that multiple i.p. injections do not cause any ill effects in mice.",

author = "Davis, {Jennifer N.} and Courtney, {Cynthia L.} and Hillary Superak and Taylor, {Douglas K.}",

note = "Funding Information: We thank the Biomarkers Core Laboratory at the Yerkes National Primate Research Center, which is supported by a Yerkes National Primate Research Center Base Grant, for providing assay services. We also thank Rebeccah Hunter, Cherie Lawley, Karen Lieber and Kristy Weed of the Division of Animal Resources at Emory University for their technical support.",

year = "2014",

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doi = "10.1038/laban.433",

language = "English (US)",

volume = "43",

pages = "131--139",

journal = "Lab Animal",

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AU - Davis, Jennifer N.

AU - Courtney, Cynthia L.

AU - Superak, Hillary

AU - Taylor, Douglas K.

N1 - Funding Information: We thank the Biomarkers Core Laboratory at the Yerkes National Primate Research Center, which is supported by a Yerkes National Primate Research Center Base Grant, for providing assay services. We also thank Rebeccah Hunter, Cherie Lawley, Karen Lieber and Kristy Weed of the Division of Animal Resources at Emory University for their technical support.

PY - 2014/4

Y1 - 2014/4

N2 - Pharmacological agents are commonly administered to mice through multiple intraperitoneal (i.p.) injections. The i.p. route of administration is usually considered safe, but questions of animal welfare arise when protocols require that multiple injections be given to the same animal. IACUCs must consider the potential risks associated with multiple i.p. injections in order to determine the maximum number of injections an animal can receive within a study protocol, but there are no published studies of such potential risks. The authors investigated the effects of 30 daily i.p. saline injections on the behavior, body condition, weight, fecal corticosterone levels, hematology and pathology of female adult mice. Results indicate that multiple i.p. injections do not cause any ill effects in mice.

AB - Pharmacological agents are commonly administered to mice through multiple intraperitoneal (i.p.) injections. The i.p. route of administration is usually considered safe, but questions of animal welfare arise when protocols require that multiple injections be given to the same animal. IACUCs must consider the potential risks associated with multiple i.p. injections in order to determine the maximum number of injections an animal can receive within a study protocol, but there are no published studies of such potential risks. The authors investigated the effects of 30 daily i.p. saline injections on the behavior, body condition, weight, fecal corticosterone levels, hematology and pathology of female adult mice. Results indicate that multiple i.p. injections do not cause any ill effects in mice.

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Behavioral, clinical and pathological effects of multiple daily intraperitoneal injections on female mice

Abstract

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