Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling

Risheng Xu, Anthony V. Serritella, Tanusree Sen, Justin M. Farook, ThomasW Sedlak, Jay Baraban, Solomon H. Snyder, Nilkantha Sen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cocaine@s behavioral-stimulant effects derive from potentiation of synaptic signaling by dopamine and serotonin leading to transcriptional alterations in postsynaptic cells. We report that a signaling cascade involving nitric oxide (NO) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mediates cocaine@s transcriptional and behavioral actions. Lower, behavioral-stimulant doses enhance the cAMP response element-binding (CREB) signaling system, while higher, neurotoxic doses stimulate the p53 cytotoxic system. The drug CGP3466B, which potently and selectively blocks GAPDH nitrosylation and GAPDH-Siah binding, prevents these actions as well as behavioral effects of cocaine providing a strategy for anticocaine therapy

Original languageEnglish (US)
Pages (from-to)623-630
Number of pages8
JournalNeuron
Volume78
Issue number4
DOIs
StatePublished - May 22 2013

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Glyceraldehyde-3-Phosphate Dehydrogenases
Cocaine
Nitric Oxide
Response Elements
Dopamine
Serotonin
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Xu, R., Serritella, A. V., Sen, T., Farook, J. M., Sedlak, T., Baraban, J., ... Sen, N. (2013). Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. Neuron, 78(4), 623-630. https://doi.org/10.1016/j.neuron.2013.03.021

Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. / Xu, Risheng; Serritella, Anthony V.; Sen, Tanusree; Farook, Justin M.; Sedlak, ThomasW; Baraban, Jay; Snyder, Solomon H.; Sen, Nilkantha.

In: Neuron, Vol. 78, No. 4, 22.05.2013, p. 623-630.

Research output: Contribution to journalArticle

Xu, R, Serritella, AV, Sen, T, Farook, JM, Sedlak, T, Baraban, J, Snyder, SH & Sen, N 2013, 'Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling', Neuron, vol. 78, no. 4, pp. 623-630. https://doi.org/10.1016/j.neuron.2013.03.021
Xu R, Serritella AV, Sen T, Farook JM, Sedlak T, Baraban J et al. Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. Neuron. 2013 May 22;78(4):623-630. https://doi.org/10.1016/j.neuron.2013.03.021
Xu, Risheng ; Serritella, Anthony V. ; Sen, Tanusree ; Farook, Justin M. ; Sedlak, ThomasW ; Baraban, Jay ; Snyder, Solomon H. ; Sen, Nilkantha. / Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. In: Neuron. 2013 ; Vol. 78, No. 4. pp. 623-630.
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