Behavioral reinforcement of long-term potentiation in rat dentate gyrus in vivo is protein synthesis-dependent

Jorge A. Bergado, W. Almaguer-Melian, Sergiy Kostenko, Sabine Martina Frey, Julietta Uta Frey

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A transient, protein synthesis-independent long-term potentiation (early-LTP, <4 h) can be reinforced into a maintained protein synthesis-dependent late-LTP (>4 h) by specific electrical stimulation of limbic structures (J. Neurosci. 21 (2001) 3697). Similarly, LTP-modulation can be obtained by behavioral stimuli with strong motivational content. However, the requirement of protein synthesis during behavioral reinforcement has not been shown so far. Thus, we have studied here this specific question using a behavioral reinforcement protocol, i.e. allowing water-deprived animals to drink 15 min after induction of early-LTP. This procedure transformed early-LTP into late-LTP. Anisomycin, a reversible protein synthesis inhibitor, abolished behavioral LTP-reinforcement. These results demonstrate that behavioral reinforcement depends on protein synthesis.

Original languageEnglish (US)
Pages (from-to)56-58
Number of pages3
JournalNeuroscience Letters
Volume351
Issue number1
DOIs
StatePublished - Nov 6 2003

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Long-Term Potentiation
Dentate Gyrus
Anisomycin
Proteins
Protein Synthesis Inhibitors
Electric Stimulation
Water

Keywords

  • Anisomycin
  • Behavioral reinforcement
  • Dentate gyrus
  • Hippocampus
  • Late-long-term potentiation
  • Long-term potentiation
  • Protein synthesis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Behavioral reinforcement of long-term potentiation in rat dentate gyrus in vivo is protein synthesis-dependent. / Bergado, Jorge A.; Almaguer-Melian, W.; Kostenko, Sergiy; Frey, Sabine Martina; Frey, Julietta Uta.

In: Neuroscience Letters, Vol. 351, No. 1, 06.11.2003, p. 56-58.

Research output: Contribution to journalArticle

Bergado, Jorge A. ; Almaguer-Melian, W. ; Kostenko, Sergiy ; Frey, Sabine Martina ; Frey, Julietta Uta. / Behavioral reinforcement of long-term potentiation in rat dentate gyrus in vivo is protein synthesis-dependent. In: Neuroscience Letters. 2003 ; Vol. 351, No. 1. pp. 56-58.
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