Behavioral state-specific changes in human hippocampal theta activity

K. J. Meador, J. L. Thompson, D. W. Loring, Anthony M Murro, D. W. King, B. B. Gallagher, G. P. Lee, J. R. Smith, H. F. Flanigin

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Abstract

Although there has been extensive examination of the behavioral and physiologic correlates of hippocampal theta activity in animals, the human literature consists of a single case study. We investigated the differential effects of four behavioral states on human hippocampal theta activity in 16 epilepsy surgery patients. Behavioral conditions included resting eyes closed (RC), resting eyes open (RO), eyes open with auditory word activation (AW), and eyes open with visuospatial activation (VS). Hippocampal theta activity decreased during both RO and VS compared to both RC and AW. There were reciprocal changes in delta activity. Comparisons of RO to VS and of RC to AW were nonsignificant. The results demonstrate state-specific changes in human hippocampal theta and are consistent with the animal literature that relates hippocampal theta to sensorimotor integration and forebrain volitional mechanisms.

Original languageEnglish (US)
Pages (from-to)869-872
Number of pages4
JournalNeurology
Volume41
Issue number6
StatePublished - Jan 1 1991

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Prosencephalon
Epilepsy

ASJC Scopus subject areas

  • Clinical Neurology

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Meador, K. J., Thompson, J. L., Loring, D. W., Murro, A. M., King, D. W., Gallagher, B. B., ... Flanigin, H. F. (1991). Behavioral state-specific changes in human hippocampal theta activity. Neurology, 41(6), 869-872.

Behavioral state-specific changes in human hippocampal theta activity. / Meador, K. J.; Thompson, J. L.; Loring, D. W.; Murro, Anthony M; King, D. W.; Gallagher, B. B.; Lee, G. P.; Smith, J. R.; Flanigin, H. F.

In: Neurology, Vol. 41, No. 6, 01.01.1991, p. 869-872.

Research output: Contribution to journalArticle

Meador, KJ, Thompson, JL, Loring, DW, Murro, AM, King, DW, Gallagher, BB, Lee, GP, Smith, JR & Flanigin, HF 1991, 'Behavioral state-specific changes in human hippocampal theta activity', Neurology, vol. 41, no. 6, pp. 869-872.
Meador KJ, Thompson JL, Loring DW, Murro AM, King DW, Gallagher BB et al. Behavioral state-specific changes in human hippocampal theta activity. Neurology. 1991 Jan 1;41(6):869-872.
Meador, K. J. ; Thompson, J. L. ; Loring, D. W. ; Murro, Anthony M ; King, D. W. ; Gallagher, B. B. ; Lee, G. P. ; Smith, J. R. ; Flanigin, H. F. / Behavioral state-specific changes in human hippocampal theta activity. In: Neurology. 1991 ; Vol. 41, No. 6. pp. 869-872.
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