beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya.

P. J. Ojwang, T. Ogada, J. M. Gonzalez-Redondo, Abdullah Kutlar, Ferdane Kutlar, T. H. Huisman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this paper, we present data on studies of beta S-haplotypes and alpha-thalassemia gene in subjects from the indigenous population of the Coast Province of Kenya Of the 7SS patients studied, four were homozygous for beta S-haplotype 20 characteristically associated with the severe form of sickle cell anemia found in the Central African Republic and Western Kenya. Two had haplotype 20 combined with haplotype 19 (Benin Type) and one had haplotype 20 combined with a new haplotype (20x). Alpha thalassaemia-2 gene (-3.7kb deletion) was detected in 45.6% of the 57AA subjects studied. An alpha globin gene triplication was detected in one subject whereas eight had gamma globin gene triplication.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalEast African Medical Journal
Volume66
Issue number6
StatePublished - Jun 1 1989

Fingerprint

alpha-Thalassemia
Kenya
Haplotypes
Genes
gamma-Globins
alpha-Globins
Central African Republic
Benin
Coastal zones
Gene Deletion
Sickle Cell Anemia
Population Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ojwang, P. J., Ogada, T., Gonzalez-Redondo, J. M., Kutlar, A., Kutlar, F., & Huisman, T. H. (1989). beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya. East African Medical Journal, 66(6), 377-380.

beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya. / Ojwang, P. J.; Ogada, T.; Gonzalez-Redondo, J. M.; Kutlar, Abdullah; Kutlar, Ferdane; Huisman, T. H.

In: East African Medical Journal, Vol. 66, No. 6, 01.06.1989, p. 377-380.

Research output: Contribution to journalArticle

Ojwang, PJ, Ogada, T, Gonzalez-Redondo, JM, Kutlar, A, Kutlar, F & Huisman, TH 1989, 'beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya.', East African Medical Journal, vol. 66, no. 6, pp. 377-380.
Ojwang PJ, Ogada T, Gonzalez-Redondo JM, Kutlar A, Kutlar F, Huisman TH. beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya. East African Medical Journal. 1989 Jun 1;66(6):377-380.
Ojwang, P. J. ; Ogada, T. ; Gonzalez-Redondo, J. M. ; Kutlar, Abdullah ; Kutlar, Ferdane ; Huisman, T. H. / beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya. In: East African Medical Journal. 1989 ; Vol. 66, No. 6. pp. 377-380.
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