Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone

Jessica Andrea Filosa, H. W. Morrison, J. A. Iddings, W. Du, K. J. Kim

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

The brain possesses two intricate mechanisms that fulfill its continuous metabolic needs: cerebral autoregulation, which ensures constant cerebral blood flow over a wide range of arterial pressures and functional hyperemia, which ensures rapid delivery of oxygen and glucose to active neurons. Over the past decade, a number of important studies have identified astrocytes as key intermediaries in neurovascular coupling (NVC), the mechanism by which active neurons signal blood vessels to change their diameter. Activity-dependent increases in astrocytic Ca2+ activity are thought to contribute to the release of vasoactive substances that facilitate arteriole vasodilation. A number of vasoactive signals have been identified and their role on vessel caliber assessed both in vitro and in vivo. In this review, we discuss mechanisms implicating astrocytes in NVC-mediated vascular responses, limitations encountered as a result of the challenges in maintaining all the constituents of the neurovascular unit intact and deliberate current controversial findings disputing a main role for astrocytes in NVC. Finally, we briefly discuss the potential role of pericytes and microglia in NVC-mediated processes.

Original languageEnglish (US)
Pages (from-to)96-109
Number of pages14
JournalNeuroscience
Volume323
DOIs
StatePublished - May 26 2016

Fingerprint

Astrocytes
Blood Vessels
Cerebrovascular Circulation
Neurons
Pericytes
Hyperemia
Microglia
Arterioles
Vasodilation
Arterial Pressure
Homeostasis
Oxygen
Glucose
Neurovascular Coupling
Brain

Keywords

  • Astrocyte
  • Calcium
  • Cerebral blood flow
  • Myogenic tone
  • Neurovascular coupling

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone. / Filosa, Jessica Andrea; Morrison, H. W.; Iddings, J. A.; Du, W.; Kim, K. J.

In: Neuroscience, Vol. 323, 26.05.2016, p. 96-109.

Research output: Contribution to journalReview article

Filosa, Jessica Andrea ; Morrison, H. W. ; Iddings, J. A. ; Du, W. ; Kim, K. J. / Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone. In: Neuroscience. 2016 ; Vol. 323. pp. 96-109.
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