Bidirectional modulation of long-term potentiation by novelty-exploration in rat dentate gyrus

Thomas Straube, Volker Korz, Julietta U. Frey

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Abstract

Previous studies have shown that exploration of a novel environment reverses hippocampal long-term potentiation (LTP). Here we demonstrate a bidirectional modulation of LTP measured in the dentate gyrus of freely moving rats by means of novelty exploration. A transient form of LTP lasting about 6 h was induced in perforant path-granular cell-synapses by a weak tetanization protocol (three bursts of 15 pulses at f=200 Hz). LTP was reversed when non-restricted exploration of a novel environment started 2 min after LTP induction. In contrast, using the same interval and limiting the exploration duration to 1 min led to LTP-prolongation. Furthermore, LTP-reinforcement was also obtained when a not-restricted exploration started within 2 min before tetanization. The observed interplay of LTP-impairing and -enhancing factors may be relevant for the modulation of memory formation by novelty.

Original languageEnglish (US)
Pages (from-to)5-8
Number of pages4
JournalNeuroscience Letters
Volume344
Issue number1
DOIs
StatePublished - Jun 19 2003

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Keywords

  • Dentate gyrus
  • LTP-reinforcement
  • LTP-reversal
  • Late-LTP
  • Learning
  • Long-term potentiation
  • Memory formation
  • Novelty

ASJC Scopus subject areas

  • Neuroscience(all)

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