Bidirectional neuro-glial signaling modalities in the hypothalamus

Role in neurohumoral regulation

Javier Eduardo Stern, Jessica Andrea Filosa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Maintenance of bodily homeostasis requires concerted interactions between the neuroendocrine and the autonomic nervous systems, which generate adaptive neurohumoral outflows in response to a variety of sensory inputs. Moreover, an exacerbated neurohumoral activation is recognized to be a critical component in numerous disease conditions, including hypertension, heart failure, stress, and the metabolic syndrome. Thus, the study of neurohumoral regulation in the brain is of critical physiological and pathological relevance. Most of the work in the field over the last decades has been centered on elucidating neuronal mechanisms and pathways involved in neurohumoral control. More recently however, it has become increasingly clear that non-neuronal cell types, particularly astrocytes and microglial cells, actively participate in information processing in areas of the brain involved in neuroendocrine and autonomic control. Thus, in this work, we review recent advances in our understanding of neuro-glial interactions within the hypothalamic supraoptic and paraventricular nuclei, and their impact on neurohumoral integration in these nuclei. Major topics reviewed include anatomical and functional properties of the neuro-glial microenvironment, neuron-to-astrocyte signaling, gliotransmitters, and astrocyte regulation of signaling molecules in the extracellular space. We aimed in this review to highlight the importance of neuro-glial bidirectional interactions in information processing within major hypothalamic networks involved in neurohumoral integration.

Original languageEnglish (US)
Pages (from-to)51-60
Number of pages10
JournalAutonomic Neuroscience: Basic and Clinical
Volume175
Issue number1-2
DOIs
StatePublished - Apr 1 2013

Fingerprint

Neuroglia
Astrocytes
Hypothalamus
Automatic Data Processing
Supraoptic Nucleus
Autonomic Nervous System
Brain
Extracellular Space
Homeostasis
Heart Failure
Maintenance
Hypertension
Neurons

Keywords

  • Astrocytes
  • GABA
  • Glutamate
  • Microglia
  • Neuroendocrine
  • Nitric oxide
  • Oxytocin
  • Paraventricular
  • Supraoptic
  • Sympathetic
  • Vasopressin

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Bidirectional neuro-glial signaling modalities in the hypothalamus : Role in neurohumoral regulation. / Stern, Javier Eduardo; Filosa, Jessica Andrea.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 175, No. 1-2, 01.04.2013, p. 51-60.

Research output: Contribution to journalArticle

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