Biginelli reaction: A green perspective

Siva Shankar Panda, Pankaj Khannab, Leena Khannac

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The Biginelli Reaction is a one-pot acid catalysed cyclocondensation of β-keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalised 3,4-dihydro-2(H)-pyrimidinones (DHPMs). This three-component reaction for the synthesis of dihydropyrimidinone and corresponding dihydropyrimidinethiones has now been known for more than a century since first reported in 1893. Owing to the increasing use of Green technology approach, due to its various merits over Classical methodology and as a need for sustainable Chemistry, this reaction has received renewed interest for preparing DHPMs in an environmentally thoughtful manner with improved yields. The classical reaction has been modified in the recent past by using various catalysts and several structural variants in different solvents to synthesize large number of Biginelli type compounds. Also, these DHPMs (synthetic and natural) possess a wide range of pharmacological activities. We hereby wish to compile, in this present review, the literature available methods related to large number of Biginelli type compounds synthesized using eco-friendly technologies. This protocol couples the benefits of Biginelli reaction with that of greener approach for organic transformations, thus facilitating efficient synthesis of bioactive compounds in environmentally benign way.

Original languageEnglish (US)
Pages (from-to)95-108
Number of pages14
JournalCurrent Organic Chemistry
Volume16
Issue number4
StatePublished - Feb 1 2012

Fingerprint

Pyrimidinones
Environmental technology
Aldehydes
Urea
Esters
Catalysts
Acids

Keywords

  • Dihydropyrimidinethione
  • Dihydropyrimidinone
  • Ionic liquid
  • Microwave
  • Multicomponent reactions
  • Water

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Panda, S. S., Khannab, P., & Khannac, L. (2012). Biginelli reaction: A green perspective. Current Organic Chemistry, 16(4), 95-108.

Biginelli reaction : A green perspective. / Panda, Siva Shankar; Khannab, Pankaj; Khannac, Leena.

In: Current Organic Chemistry, Vol. 16, No. 4, 01.02.2012, p. 95-108.

Research output: Contribution to journalArticle

Panda, SS, Khannab, P & Khannac, L 2012, 'Biginelli reaction: A green perspective', Current Organic Chemistry, vol. 16, no. 4, pp. 95-108.
Panda SS, Khannab P, Khannac L. Biginelli reaction: A green perspective. Current Organic Chemistry. 2012 Feb 1;16(4):95-108.
Panda, Siva Shankar ; Khannab, Pankaj ; Khannac, Leena. / Biginelli reaction : A green perspective. In: Current Organic Chemistry. 2012 ; Vol. 16, No. 4. pp. 95-108.
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