Bimodal antibacterial system based on quaternary ammonium silane-coupled core-shell hollow mesoporous silica

Yu ming Bai, Jing Mao, De xiong Li, Xiao juan Luo, Jiang Chen, Franklin Chi Meng Tay, Li na Niu

Research output: Contribution to journalArticle

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Abstract

Hollow mesoporous silica (HMS) have been extensively investigated as a biomaterial for drug delivery. The present study developed quaternary ammonium silane-grafted hollow mesoporous silica (QHMS) to create a metronidazole (MDZ) sustained delivery system, MDZ@QHMS, with bimodal, contact-kill and release-kill capability. The QHMS was assembled through a self-templating method. Metronidazole was incorporated within the QHMS core using solvent evaporation. Antibacterial activities of the MDZ@QHMS were investigated using single-species biofilms of Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC25922) and Porphyromonas gingivalis (ATCC33277). The MDZ@QHMS maintained a hollow mesoporous structure and demonstrated sustained drug release and bacteridal actvity against the three bacterial strains at a concentration of 100 μg/mL or above. These nanoparticles were not relatively cytotoxic to human gingival fibroblasts when employed below 100 µg/mL. Compared with HMS, the MDZ@QHMS system at the same concentration demonstrated antibiotic-elution and contact-killing bimodal antibacterial activities. The synthesized drug carrier with sustained, bimodal antibacterial function and minimal cytotoxicity possesses potential for localized antibiotic applications. Statement of Significance: The present study develops quaternary ammonium silane-grafted hollow mesoporous silica (QHMS) to create a metronidazole (MDZ) sustained delivery system, MDZ@QHMS, with bimodal, contact-kill and release-kill capability. This system demonstrates sustained drug release and maintained a hollow mesoporous structure. The synthesized drug carrier with sustained, bimodal antibacterial function and excellent biocompatibility possesses potential for localized antibiotic applications.

Original languageEnglish (US)
Pages (from-to)229-240
Number of pages12
JournalActa biomaterialia
Volume85
DOIs
StatePublished - Feb 1 2019

Fingerprint

Silanes
Metronidazole
Ammonium Compounds
Silicon Dioxide
Antibiotics
Silica
Drug Carriers
Biofilms
Fibroblasts
Cytotoxicity
Anti-Bacterial Agents
Drug delivery
Biocompatibility
Biomaterials
Escherichia coli
Evaporation
Nanoparticles
Porphyromonas gingivalis
Biocompatible Materials
Pharmaceutical Preparations

Keywords

  • Antibacterial
  • Hollow mesoporous silica
  • Metronidazole
  • Quaternary ammonium methacrylate silicate

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Bimodal antibacterial system based on quaternary ammonium silane-coupled core-shell hollow mesoporous silica. / Bai, Yu ming; Mao, Jing; Li, De xiong; Luo, Xiao juan; Chen, Jiang; Tay, Franklin Chi Meng; Niu, Li na.

In: Acta biomaterialia, Vol. 85, 01.02.2019, p. 229-240.

Research output: Contribution to journalArticle

Bai, Yu ming ; Mao, Jing ; Li, De xiong ; Luo, Xiao juan ; Chen, Jiang ; Tay, Franklin Chi Meng ; Niu, Li na. / Bimodal antibacterial system based on quaternary ammonium silane-coupled core-shell hollow mesoporous silica. In: Acta biomaterialia. 2019 ; Vol. 85. pp. 229-240.
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AU - Chen, Jiang

AU - Tay, Franklin Chi Meng

AU - Niu, Li na

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AB - Hollow mesoporous silica (HMS) have been extensively investigated as a biomaterial for drug delivery. The present study developed quaternary ammonium silane-grafted hollow mesoporous silica (QHMS) to create a metronidazole (MDZ) sustained delivery system, MDZ@QHMS, with bimodal, contact-kill and release-kill capability. The QHMS was assembled through a self-templating method. Metronidazole was incorporated within the QHMS core using solvent evaporation. Antibacterial activities of the MDZ@QHMS were investigated using single-species biofilms of Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC25922) and Porphyromonas gingivalis (ATCC33277). The MDZ@QHMS maintained a hollow mesoporous structure and demonstrated sustained drug release and bacteridal actvity against the three bacterial strains at a concentration of 100 μg/mL or above. These nanoparticles were not relatively cytotoxic to human gingival fibroblasts when employed below 100 µg/mL. Compared with HMS, the MDZ@QHMS system at the same concentration demonstrated antibiotic-elution and contact-killing bimodal antibacterial activities. The synthesized drug carrier with sustained, bimodal antibacterial function and minimal cytotoxicity possesses potential for localized antibiotic applications. Statement of Significance: The present study develops quaternary ammonium silane-grafted hollow mesoporous silica (QHMS) to create a metronidazole (MDZ) sustained delivery system, MDZ@QHMS, with bimodal, contact-kill and release-kill capability. This system demonstrates sustained drug release and maintained a hollow mesoporous structure. The synthesized drug carrier with sustained, bimodal antibacterial function and excellent biocompatibility possesses potential for localized antibiotic applications.

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