Bimodal antibacterial system based on quaternary ammonium silane-coupled core-shell hollow mesoporous silica

Yu ming Bai, Jing Mao, De xiong Li, Xiao juan Luo, Jiang Chen, Franklin R. Tay, Li na Niu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Hollow mesoporous silica (HMS) have been extensively investigated as a biomaterial for drug delivery. The present study developed quaternary ammonium silane-grafted hollow mesoporous silica (QHMS) to create a metronidazole (MDZ) sustained delivery system, MDZ@QHMS, with bimodal, contact-kill and release-kill capability. The QHMS was assembled through a self-templating method. Metronidazole was incorporated within the QHMS core using solvent evaporation. Antibacterial activities of the MDZ@QHMS were investigated using single-species biofilms of Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC25922) and Porphyromonas gingivalis (ATCC33277). The MDZ@QHMS maintained a hollow mesoporous structure and demonstrated sustained drug release and bacteridal actvity against the three bacterial strains at a concentration of 100 μg/mL or above. These nanoparticles were not relatively cytotoxic to human gingival fibroblasts when employed below 100 µg/mL. Compared with HMS, the MDZ@QHMS system at the same concentration demonstrated antibiotic-elution and contact-killing bimodal antibacterial activities. The synthesized drug carrier with sustained, bimodal antibacterial function and minimal cytotoxicity possesses potential for localized antibiotic applications. Statement of Significance: The present study develops quaternary ammonium silane-grafted hollow mesoporous silica (QHMS) to create a metronidazole (MDZ) sustained delivery system, MDZ@QHMS, with bimodal, contact-kill and release-kill capability. This system demonstrates sustained drug release and maintained a hollow mesoporous structure. The synthesized drug carrier with sustained, bimodal antibacterial function and excellent biocompatibility possesses potential for localized antibiotic applications.

Original languageEnglish (US)
Pages (from-to)229-240
Number of pages12
JournalActa biomaterialia
Volume85
DOIs
StatePublished - Feb 2019

Keywords

  • Antibacterial
  • Hollow mesoporous silica
  • Metronidazole
  • Quaternary ammonium methacrylate silicate

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Fingerprint Dive into the research topics of 'Bimodal antibacterial system based on quaternary ammonium silane-coupled core-shell hollow mesoporous silica'. Together they form a unique fingerprint.

Cite this