Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival

Arezoo Ghaneie, Vlasta Zemba-Palko, Hiromichi Itoh, Kaori Itoh, Daitoku Sakamuro, Seigo Nakamura, Alejandro Peralta Soler, George C. Prendergast

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Clinical outcomes in breast cancer are likely influenced by modifier genes that affect tumor dormancy versus progression. The Bin1 gene encodes a nucleocytosolic adapter protein that suppresses neoplastic cell transformation and that is often attenuated in human breast carcinoma. Recent mouse genetic studies indicate that Bin1 loss cooperates with ras activation to drive progression of mammary carcinoma, establishing Bin1 as a negative modifier of tumor progression in breast cancer. In this study, we investigated whether immunohistochemical losses of nuclear Bin1 proteins in cases of human breast cancer were correlated to progression status. In American and Japanese groups of low or middle grade breast cancers, losses were associated with reduced survival and increased nodal metastasis, respectively. Taken together with recent findings from mouse genetic studies, these findings encourage further evaluation of the potential utility of Bin1 as a clinical prognostic marker in breast cancer.

Original languageEnglish (US)
Pages (from-to)192-194
Number of pages3
JournalCancer Biology and Therapy
Volume6
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

Keywords

  • Amphiphysin II
  • Breast cancer
  • Myc
  • Ras

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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    Ghaneie, A., Zemba-Palko, V., Itoh, H., Itoh, K., Sakamuro, D., Nakamura, S., Soler, A. P., & Prendergast, G. C. (2007). Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival. Cancer Biology and Therapy, 6(2), 192-194. https://doi.org/10.4161/cbt.6.2.3587