BIN1 is a novel MYC-interacting protein with features of a tumour suppressor

Daitoku Sakamuro, Katherine J. Elliott, Robert Wechsler-Reya, George C. Prendergast

Research output: Contribution to journalArticle

270 Citations (Scopus)

Abstract

BIN1 is a novel protein that interacts with the functionally critical Myc box regions at the N terminus of the MYC oncoprotein. BIN1 is structurally related to amphiphysin, a breast cancer-associated autoimmune antigen, and RVS167, a negative regulator of the yeast cell cycle, suggesting roles in malignancy and cell cycle control. Consistent with this likelihood, BIN1 inhibited malignant cell transformation by MYC. Although BIN1 is expressed in many normal cells, its levels were greatly reduced or undetectable in 14/27 carcinoma cell lines and 3/6 primary breast tumours. Deficits were functionally significant because ectopic expression of BIN1 inhibited the growth of tumour cells lacking endogenous message. We conclude that BIN1 is an MYC-interacting protein with features of a tumour suppressor.

Original languageEnglish (US)
Pages (from-to)69-77
Number of pages9
JournalNature Genetics
Volume14
Issue number1
DOIs
StatePublished - Sep 1 1996
Externally publishedYes

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Breast Neoplasms
Neoplasms
Proteins
Oncogene Proteins
Cell Cycle Checkpoints
Cell Cycle
Yeasts
Carcinoma
Antigens
Cell Line
Growth
amphiphysin
Ectopic Gene Expression

ASJC Scopus subject areas

  • Genetics

Cite this

BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. / Sakamuro, Daitoku; Elliott, Katherine J.; Wechsler-Reya, Robert; Prendergast, George C.

In: Nature Genetics, Vol. 14, No. 1, 01.09.1996, p. 69-77.

Research output: Contribution to journalArticle

Sakamuro, Daitoku ; Elliott, Katherine J. ; Wechsler-Reya, Robert ; Prendergast, George C. / BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. In: Nature Genetics. 1996 ; Vol. 14, No. 1. pp. 69-77.
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