Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin

Yaakov Naparstek, Arie Ben‐Yehuda, Michael P. Madaio, Ruth Bar‐Tana, Lucy Schuger, Galina Pizov, Zvi Neeman, Irun R. Cohen

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL‐lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL‐lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low‐dose heparin might be useful in preventing renal damage in patients with lupus nephritis.

Original languageEnglish (US)
Pages (from-to)1554-1559
Number of pages6
JournalArthritis & Rheumatism
Volume33
Issue number10
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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Glomerulonephritis
Heparin
Kidney
Antibodies
Lupus Nephritis
Systemic Lupus Erythematosus
DNA
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Naparstek, Y., Ben‐Yehuda, A., Madaio, M. P., Bar‐Tana, R., Schuger, L., Pizov, G., ... Cohen, I. R. (1990). Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin. Arthritis & Rheumatism, 33(10), 1554-1559. https://doi.org/10.1002/art.1780331013

Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin. / Naparstek, Yaakov; Ben‐Yehuda, Arie; Madaio, Michael P.; Bar‐Tana, Ruth; Schuger, Lucy; Pizov, Galina; Neeman, Zvi; Cohen, Irun R.

In: Arthritis & Rheumatism, Vol. 33, No. 10, 01.01.1990, p. 1554-1559.

Research output: Contribution to journalArticle

Naparstek, Y, Ben‐Yehuda, A, Madaio, MP, Bar‐Tana, R, Schuger, L, Pizov, G, Neeman, Z & Cohen, IR 1990, 'Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin', Arthritis & Rheumatism, vol. 33, no. 10, pp. 1554-1559. https://doi.org/10.1002/art.1780331013
Naparstek Y, Ben‐Yehuda A, Madaio MP, Bar‐Tana R, Schuger L, Pizov G et al. Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin. Arthritis & Rheumatism. 1990 Jan 1;33(10):1554-1559. https://doi.org/10.1002/art.1780331013
Naparstek, Yaakov ; Ben‐Yehuda, Arie ; Madaio, Michael P. ; Bar‐Tana, Ruth ; Schuger, Lucy ; Pizov, Galina ; Neeman, Zvi ; Cohen, Irun R. / Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin. In: Arthritis & Rheumatism. 1990 ; Vol. 33, No. 10. pp. 1554-1559.
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