Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin

Yaakov Naparstek, Arie Ben‐Yehuda, Michael P. Madaio, Ruth Bar‐Tana, Lucy Schuger, Galina Pizov, Zvi Neeman, Irun R. Cohen

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL‐lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL‐lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low‐dose heparin might be useful in preventing renal damage in patients with lupus nephritis.

Original languageEnglish (US)
Pages (from-to)1554-1559
Number of pages6
JournalArthritis & Rheumatism
Volume33
Issue number10
DOIs
StatePublished - Oct 1990

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Naparstek, Y., Ben‐Yehuda, A., Madaio, M. P., Bar‐Tana, R., Schuger, L., Pizov, G., Neeman, Z., & Cohen, I. R. (1990). Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin. Arthritis & Rheumatism, 33(10), 1554-1559. https://doi.org/10.1002/art.1780331013