Binding of T cell receptor to major histocompatibility complex class II‐peptide complexes at the single‐cell level results in the induction of antigen unresponsiveness (anergy)

Esteban Celis, Toshiji Saibara

Research output: Contribution to journalArticle

30 Scopus citations


Using dispersion cultures performed in semi‐solid medium we demonstrate here that the interaction of T cell antigen receptor molecules with Ia‐peptide complexes on the same cell surface results in T cell activation, without the production of lymphokines. This recognition of antigen at the single‐cell level, induced a state of anergy which was not due to a decrease of surface T cell antigen receptor/CD3 complexes. The induction of anergy by peptide could not be prevented by the addition of various co‐stimulatory signals, including antibodies to CD28, or CD2, high doses of interleukin‐2 or phorbol ester.

Original languageEnglish (US)
Pages (from-to)3127-3134
Number of pages8
JournalEuropean Journal of Immunology
Issue number12
StatePublished - Jan 1 1992
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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