TY - JOUR
T1 - Binding of T cell receptor to major histocompatibility complex class II‐peptide complexes at the single‐cell level results in the induction of antigen unresponsiveness (anergy)
AU - Celis, Esteban
AU - Saibara, Toshiji
PY - 1992/12
Y1 - 1992/12
N2 - Using dispersion cultures performed in semi‐solid medium we demonstrate here that the interaction of T cell antigen receptor molecules with Ia‐peptide complexes on the same cell surface results in T cell activation, without the production of lymphokines. This recognition of antigen at the single‐cell level, induced a state of anergy which was not due to a decrease of surface T cell antigen receptor/CD3 complexes. The induction of anergy by peptide could not be prevented by the addition of various co‐stimulatory signals, including antibodies to CD28, or CD2, high doses of interleukin‐2 or phorbol ester.
AB - Using dispersion cultures performed in semi‐solid medium we demonstrate here that the interaction of T cell antigen receptor molecules with Ia‐peptide complexes on the same cell surface results in T cell activation, without the production of lymphokines. This recognition of antigen at the single‐cell level, induced a state of anergy which was not due to a decrease of surface T cell antigen receptor/CD3 complexes. The induction of anergy by peptide could not be prevented by the addition of various co‐stimulatory signals, including antibodies to CD28, or CD2, high doses of interleukin‐2 or phorbol ester.
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U2 - 10.1002/eji.1830221215
DO - 10.1002/eji.1830221215
M3 - Article
C2 - 1446705
AN - SCOPUS:0026480810
SN - 0014-2980
VL - 22
SP - 3127
EP - 3134
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 12
ER -