Using dispersion cultures performed in semi‐solid medium we demonstrate here that the interaction of T cell antigen receptor molecules with Ia‐peptide complexes on the same cell surface results in T cell activation, without the production of lymphokines. This recognition of antigen at the single‐cell level, induced a state of anergy which was not due to a decrease of surface T cell antigen receptor/CD3 complexes. The induction of anergy by peptide could not be prevented by the addition of various co‐stimulatory signals, including antibodies to CD28, or CD2, high doses of interleukin‐2 or phorbol ester.
ASJC Scopus subject areas
- Immunology and Allergy