Bioactivity of mineral trioxide aggregate and mechanism of action

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

In tissue regeneration research, the term 'bioactivity' was initially used to describe the resistance to removal of a biomaterial from host tissues after intraosseous implantation. Mineral trioxide aggregate (MTA) and hydraulic calcium silicate cements (HCSCs) in general have been putatively accepted as bioactive materials, as exemplified by the increasing number of publications reporting that these cements are capable of forming an apatite-rich surface layer after they come into contact with simulated body fluids. The proposed mechanisms responsible for establishing in vitro and in vivo bioactivity in glass-ceramics are used as blueprints for investigating whether bioactivities are identifiable in HCSCs. The literature abounds with evidence that HCSCs exhibit in vitro bioactivity. There is a general lack of stringent methodologies for characterising the calcium phosphate phases precipitated on HCSCs. Nevertheless, the mechanisms responsible for in vitro bioactivity of these cements may be generally described in stages that are analogous to those exhibited by bioactive glasses. Although in vivo bioactivity has been demonstrated for some HCSCs, a fibrous connective tissue layer is frequently seen along the bone-cement interface that is reminiscent of the responses observed in bioinert materials, without accompanying clarifications to account for such observations. As bone bonding is not predictably achieved, there is presently insufficient scientific evidence to substantiate that HCSCs are indeed bioactive. Objective, universally acceptable appraisal criteria should be developed in the future to guide manufacturers and scientists in more accurately defining the bioactivity profiles of novel HCSCs introduced for clinical use.

Original languageEnglish (US)
Title of host publicationMineral Trioxide Aggregate in Dentistry
Subtitle of host publicationFrom Preparation to Application
PublisherSpringer-Verlag Berlin Heidelberg
Pages61-85
Number of pages25
Volume9783642551574
ISBN (Electronic)9783642551574
ISBN (Print)3642551564, 9783642551567
DOIs
StatePublished - Mar 1 2014

Fingerprint

Silicate Cement
Apatites
Bone Cements
Biocompatible Materials
Body Fluids
calcium silicate
mineral trioxide aggregate
Connective Tissue
Glass
Publications
Regeneration
Bone and Bones

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Tay, F. C. M. (2014). Bioactivity of mineral trioxide aggregate and mechanism of action. In Mineral Trioxide Aggregate in Dentistry: From Preparation to Application (Vol. 9783642551574, pp. 61-85). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-55157-4_4

Bioactivity of mineral trioxide aggregate and mechanism of action. / Tay, Franklin Chi Meng.

Mineral Trioxide Aggregate in Dentistry: From Preparation to Application. Vol. 9783642551574 Springer-Verlag Berlin Heidelberg, 2014. p. 61-85.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tay, FCM 2014, Bioactivity of mineral trioxide aggregate and mechanism of action. in Mineral Trioxide Aggregate in Dentistry: From Preparation to Application. vol. 9783642551574, Springer-Verlag Berlin Heidelberg, pp. 61-85. https://doi.org/10.1007/978-3-642-55157-4_4
Tay FCM. Bioactivity of mineral trioxide aggregate and mechanism of action. In Mineral Trioxide Aggregate in Dentistry: From Preparation to Application. Vol. 9783642551574. Springer-Verlag Berlin Heidelberg. 2014. p. 61-85 https://doi.org/10.1007/978-3-642-55157-4_4
Tay, Franklin Chi Meng. / Bioactivity of mineral trioxide aggregate and mechanism of action. Mineral Trioxide Aggregate in Dentistry: From Preparation to Application. Vol. 9783642551574 Springer-Verlag Berlin Heidelberg, 2014. pp. 61-85
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