Biochemical evidence for programmed cell death in rabbit uterine epithelium

R. J. Rotello, M. B. Hocker, L. E. Gerschenson

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Uterine epithelial cell proliferation, differentiation, and death are known to be regulated by estrogen and progesterone. The authors investigated a specific pattern of cell death called apoptosis, or programmed cell death, which is biochemically characterized by a specific pattern of DNA degradation. DNA isolated from endometrium of ovariectomized pseudopregnant rabbits showed a pattern of DNA cleavage at internucleosomal locations. In comparison, DNA from the endometrium of non-ovariectomized animals, as well as several other organs, did not exhibit that pattern. This biochemical evidence supports previous and present morphologic data and correlates with it. Under the experimental conditions used, only the uterine epithelial compartment of the endometrium shows apoptotic cell death, which is absent in the stromal compartment.

Original languageEnglish (US)
Pages (from-to)491-495
Number of pages5
JournalAmerican Journal of Pathology
Issue number3
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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