Biocompatibility of visible light-polymerized denture base resins

Dara J. Barron, George S. Schuster, Gretchen B Caughman, Carol A Lefebvre

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The biocompatibility of three commercial formulations of visible light-polymerized denture base resins was studied to determine its effects on the RNA and DNA synthesis of oral epithelial cells in vitro, isotope incorporation into RNA or DNA was measured after 24 hours of incubation with isotope and 48 hours of exposure to resin. The resins were shown to significantly inhibit the synthesis of both nucleotides as compared to a heat-processed resin control, increasing the polymerization time can mitigate the toxicity of some of the resins. The air barrier coatings used to prevent oxygen inhibition of polymerization increased the toxic effects of two resins and decreased that of one of the materials. These investigations suggest that visible light-polymerized denture resins may impair the replication of oral epithelial cells, DNA synthesis is more sensitive to the toxic effects of the materials, which may relate to the ability to cause mucosal pathology. The cytotoxic effects may relate to the presence of unpolymerized resin constituents or polymerisation by-products.

Original languageEnglish (US)
Pages (from-to)495-501
Number of pages7
JournalInternational Journal of Prosthodontics
Volume6
Issue number5
StatePublished - Jan 1 1993

Fingerprint

Denture Bases
Polymerization
Poisons
Light
Isotopes
DNA
Epithelial Cells
RNA
Dentures
Nucleotides
Hot Temperature
Air
Pathology
Oxygen

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Biocompatibility of visible light-polymerized denture base resins. / Barron, Dara J.; Schuster, George S.; Caughman, Gretchen B; Lefebvre, Carol A.

In: International Journal of Prosthodontics, Vol. 6, No. 5, 01.01.1993, p. 495-501.

Research output: Contribution to journalArticle

@article{a260dc49140e473f96973fc04e78451c,
title = "Biocompatibility of visible light-polymerized denture base resins",
abstract = "The biocompatibility of three commercial formulations of visible light-polymerized denture base resins was studied to determine its effects on the RNA and DNA synthesis of oral epithelial cells in vitro, isotope incorporation into RNA or DNA was measured after 24 hours of incubation with isotope and 48 hours of exposure to resin. The resins were shown to significantly inhibit the synthesis of both nucleotides as compared to a heat-processed resin control, increasing the polymerization time can mitigate the toxicity of some of the resins. The air barrier coatings used to prevent oxygen inhibition of polymerization increased the toxic effects of two resins and decreased that of one of the materials. These investigations suggest that visible light-polymerized denture resins may impair the replication of oral epithelial cells, DNA synthesis is more sensitive to the toxic effects of the materials, which may relate to the ability to cause mucosal pathology. The cytotoxic effects may relate to the presence of unpolymerized resin constituents or polymerisation by-products.",
author = "Barron, {Dara J.} and Schuster, {George S.} and Caughman, {Gretchen B} and Lefebvre, {Carol A}",
year = "1993",
month = "1",
day = "1",
language = "English (US)",
volume = "6",
pages = "495--501",
journal = "International Journal of Prosthodontics",
issn = "0893-2174",
publisher = "Quintessence Publishing Company",
number = "5",

}

TY - JOUR

T1 - Biocompatibility of visible light-polymerized denture base resins

AU - Barron, Dara J.

AU - Schuster, George S.

AU - Caughman, Gretchen B

AU - Lefebvre, Carol A

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The biocompatibility of three commercial formulations of visible light-polymerized denture base resins was studied to determine its effects on the RNA and DNA synthesis of oral epithelial cells in vitro, isotope incorporation into RNA or DNA was measured after 24 hours of incubation with isotope and 48 hours of exposure to resin. The resins were shown to significantly inhibit the synthesis of both nucleotides as compared to a heat-processed resin control, increasing the polymerization time can mitigate the toxicity of some of the resins. The air barrier coatings used to prevent oxygen inhibition of polymerization increased the toxic effects of two resins and decreased that of one of the materials. These investigations suggest that visible light-polymerized denture resins may impair the replication of oral epithelial cells, DNA synthesis is more sensitive to the toxic effects of the materials, which may relate to the ability to cause mucosal pathology. The cytotoxic effects may relate to the presence of unpolymerized resin constituents or polymerisation by-products.

AB - The biocompatibility of three commercial formulations of visible light-polymerized denture base resins was studied to determine its effects on the RNA and DNA synthesis of oral epithelial cells in vitro, isotope incorporation into RNA or DNA was measured after 24 hours of incubation with isotope and 48 hours of exposure to resin. The resins were shown to significantly inhibit the synthesis of both nucleotides as compared to a heat-processed resin control, increasing the polymerization time can mitigate the toxicity of some of the resins. The air barrier coatings used to prevent oxygen inhibition of polymerization increased the toxic effects of two resins and decreased that of one of the materials. These investigations suggest that visible light-polymerized denture resins may impair the replication of oral epithelial cells, DNA synthesis is more sensitive to the toxic effects of the materials, which may relate to the ability to cause mucosal pathology. The cytotoxic effects may relate to the presence of unpolymerized resin constituents or polymerisation by-products.

UR - http://www.scopus.com/inward/record.url?scp=0027653278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027653278&partnerID=8YFLogxK

M3 - Article

C2 - 7507674

AN - SCOPUS:0027653278

VL - 6

SP - 495

EP - 501

JO - International Journal of Prosthodontics

JF - International Journal of Prosthodontics

SN - 0893-2174

IS - 5

ER -