Biological activities and potential oral applications of N-acetylcysteine: Progress and prospects

Yanping Pei, Huan Liu, Yi Yang, Yanwei Yang, Yang Jiao, Franklin Chi Meng Tay, Jihua Chen

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

N-Acetylcysteine (NAC), a cysteine prodrug and glutathione (GSH) precursor, has been used for several decades in clinical therapeutic practices as a mucolytic agent and for the treatment of disorders associated with GSH deficiency. Other therapeutic activities of NAC include inhibition of inflammation/NF-κB signaling and expression of proinflammatory cytokines. N-Acetylcysteine is also a nonantibiotic compound possessing antimicrobial property and exerts anticarcinogenic and antimutagenic effects against certain types of cancer. Recently, studies describing potentially important biological and pharmacological activities of NAC have stimulated interests in using NAC-based therapeutics for oral health care. The present review focused on the biological activities of NAC and its potential oral applications. The potential side effects of NAC and formulations for drug delivery were also discussed, with the intent of advancing NAC-associated treatment modalities in oral medicine.

Original languageEnglish (US)
Article number2835787
JournalOxidative medicine and cellular longevity
Volume2018
DOIs
StatePublished - Jan 1 2018

Fingerprint

Acetylcysteine
Bioactivity
Antimutagenic Agents
Anticarcinogenic Agents
Expectorants
Oral Medicine
Drug Compounding
Oral Health
Prodrugs
Drug delivery
Health care
Medicine
Glutathione
Cysteine
Therapeutics
Pharmacology
Cytokines
Inflammation
Delivery of Health Care

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

Cite this

Biological activities and potential oral applications of N-acetylcysteine : Progress and prospects. / Pei, Yanping; Liu, Huan; Yang, Yi; Yang, Yanwei; Jiao, Yang; Tay, Franklin Chi Meng; Chen, Jihua.

In: Oxidative medicine and cellular longevity, Vol. 2018, 2835787, 01.01.2018.

Research output: Contribution to journalReview article

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abstract = "N-Acetylcysteine (NAC), a cysteine prodrug and glutathione (GSH) precursor, has been used for several decades in clinical therapeutic practices as a mucolytic agent and for the treatment of disorders associated with GSH deficiency. Other therapeutic activities of NAC include inhibition of inflammation/NF-κB signaling and expression of proinflammatory cytokines. N-Acetylcysteine is also a nonantibiotic compound possessing antimicrobial property and exerts anticarcinogenic and antimutagenic effects against certain types of cancer. Recently, studies describing potentially important biological and pharmacological activities of NAC have stimulated interests in using NAC-based therapeutics for oral health care. The present review focused on the biological activities of NAC and its potential oral applications. The potential side effects of NAC and formulations for drug delivery were also discussed, with the intent of advancing NAC-associated treatment modalities in oral medicine.",
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